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        <datestamp>2026-10-01T09:39:46Z</datestamp>
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          <dc:title>Data Sheet 1_AI-driven quality enhancement of medical datasets: a closed-loop framework of synthesis, annotation, quality control, and integration.docx</dc:title>
          <dc:creator>Tao Tian (602112)</dc:creator>
          <dc:creator>Siyuan Zhang (2044930)</dc:creator>
          <dc:creator>Xuchen Yang (7820373)</dc:creator>
          <dc:creator>Rui Shi (45165)</dc:creator>
          <dc:subject>Foetal Development and Medicine</dc:subject>
          <dc:subject>automated quality control</dc:subject>
          <dc:subject>bias detection</dc:subject>
          <dc:subject>causal reasoning</dc:subject>
          <dc:subject>intelligent annotation</dc:subject>
          <dc:subject>medical datasets</dc:subject>
          <dc:subject>privacy-preserving computation</dc:subject>
          <dc:subject>quality enhancement</dc:subject>
          <dc:subject>synthetic data</dc:subject>
          <dc:description>&lt;p&gt;The performance ceiling of medical AI is largely determined by the quality of its training datasets, yet traditional manual collection and annotation face a triple bottleneck of high cost, embedded bias, and limited scalability. This review takes “quality enhancement” as its unifying axis, integrating the four pillars of AI-driven medical dataset quality enhancement—synthetic data generation, intelligent annotation, automated quality control, and integration pipelines—and proposes a four-pillar integration framework as its core contribution. The framework organizes the four pillars into a closed loop: synthesis and annotation are coupled through dual-track feedback (a quantity track that replenishes data and a strategy track that adjusts generation strategy), while annotation and quality control are coupled through bidirectional verification. Beyond this forward enhancement loop, the framework further employs a bias amplification chain (as a heuristic insight) and the privacy–utility tradeoff as two tension lines, and incorporates Metrics Reloaded, FAIR, ALCOA+, and YY/T 1833 as sub-layer evaluation dimensions in a complementary manner. The review shows that AI-based enhancement methods have approached real data in statistical fidelity and downstream utility for select modalities, tasks, and evaluation settings, but systematic gaps remain in privacy, fairness, and clinical validity; single-pillar optimization is hypothesized, on the basis of indirect segmental evidence, to be insufficient to improve end-to-end quality, and closed-loop synergy is proposed as a testable proposition rather than an established requirement; integration pipelines are already usable for single-disease, single-modality settings, whereas cross-institutional, cross-modal, and cross-disease generalization remains the principal barrier, with federated construction and foundation-model-driven approaches as promising directions.&lt;/p&gt;</dc:description>
          <dc:date>2026-10-01T09:39:46Z</dc:date>
          <dc:type>Dataset</dc:type>
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          <dc:identifier>10.3389/fmed.2026.1947584.s001</dc:identifier>
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          <dc:rights>CC BY 4.0</dc:rights>
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