2026-10-14T08:07:18Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34041747 2026-10-01T09:16:12Z category_7 portal_147 item_type_3 month_year_10_2026

Supplemental Material for: Diagnostic Performance and Safety Profile of Shape-sensing Robotic-assisted Bronchoscopy in Peripheral Pulmonary Lesions: A Systematic Review and Meta-Analysis figshare admin karger (2628495) Xianya Hu (25155582) Lechen Wang (22212769) Jingyu Shi (4715568) Sebastian Fernandez-Bussy (7572833) Dan Liu (108669) Medicine medicine <p dir="ltr">Introduction: Shape-sensing robotic-assisted bronchoscopy (ssRAB) has emerged as a promising modality for diagnosing peripheral pulmonary lesions (PPLs). This meta-analysis evaluated its diagnostic performance and safety profile. Methods: PubMed, Embase, and Cochrane Library were searched from inception to December 2025. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-3. Random-effects model was used to estimate the pooled diagnostic yield, sensitivity for malignancy, and complication, with rates (%) and 95% confidence intervals (CI) when the I2 index exceeded 50%. Cumulative meta-analysis was performed to assess the temporal stability and evidence saturation of the pooled diagnostic yield. Publication bias was evaluated using funnel plots and Egger's test. Results: A total of 3678 lesions from 18 studies were included. Notably, diagnostic yield varied significantly by outcome definition, with pooled diagnostic yield of 82.5% (95% CI: 78.3%-86.0%) under strict definition versus 88.1% (95% CI: 82.8%-92.0%) under intermediate definition (P=0.036). The pooled sensitivity for malignancy of 90.0% (95% CI: 86.4%-92.8%). Cumulative meta-analysis showed stabilized diagnostic performance after approximately 1,500 lesions for the strict definition and 500 lesions for intermediate definition. Moreover, safety profile was favorable, with pooled rates of pneumothorax 1.8% (95% CI:1.3%-2.3%), chest tube placement 1.1% (95% CI: 0.7%-1.5%), and severe bleeding 0.0% (95% CI: 0.0%-0.3%). Subgroup analyses showed consistent performance across study designs, region, and nodule characteristics. Diagnostic yield was significantly influenced by publication year, and lesion size (P<0.05). Conclusion: ssRAB was associated with favorable, definition-dependent diagnostic yield (82.5%-88.1%) with exceptional safety, supporting ssRAB as an attractive first-line minimally invasive diagnostic option in appropriately selected patients, especially for small nodules (<2cm) and patients at elevated procedural risk.</p> 2026-10-01T09:16:12Z Dataset Dataset 10.6084/m9.figshare.34041747.v1 https://figshare.com/articles/dataset/Supplemental_Material_for_Diagnostic_Performance_and_Safety_Profile_of_Shape-sensing_Robotic-assisted_Bronchoscopy_in_Peripheral_Pulmonary_Lesions_A_Systematic_Review_and_Meta-Analysis/34041747 CC BY 4.0