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oai:figshare.com:article/34041417 2026-10-01T08:05:26Z category_4 category_7 category_8 category_14 category_19 category_21 category_873 category_46 category_734 category_64 category_106 category_132 category_133 portal_63 item_type_6 month_year_10_2026

A pH and Glucose Dual-Responsive Injectable Chitosan/ε-Polylysine Hydrogel with Inherent Antibacterial and Antioxidant Activities for Diabetic Wound Healing Huili Geng (798949) Yanjin Du (25155300) Jing Zhao (21160) Mingzhu Xie (11722652) Lina Zheng (331151) Tao Ding (129078) Bin Liu (5899) Fei Liang (483436) Na Xie (819217) Biochemistry Medicine Microbiology Molecular Biology Pharmacology Biotechnology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer Science Policy Infectious Diseases Plant Biology vitro assays demonstrated sustained hyperglycemic microenvironment responsive injectable chitosan near physiological levels multiple noncovalent interactions hyperglycemic microenvironments characteristic hinders wound healing epl ), via dynamic covalent bonds dressing might adapt diabetic wound microenvironment resistant staphylococcus aureus multifunctional hydrogel offers exhibited antibacterial rates staphylococcus aureus scavenging rates inherent antibacterial diabetic wounds tannic acid promising strategy injured wounds inflammatory phase hydrogel achieved histological analyses excellent cytocompatibility epidermal thickness design endows day 14 could help carboxyphenylboronic acid bacterial infection antioxidant activities abts radicals Diabetic wounds reside in a sustained hyperglycemic microenvironment, inducing excessive reactive oxygen species accumulation and bacterial infection, which prolongs the inflammatory phase and hinders wound healing. To address this issue, we constructed a dual-responsive hydrogel dressing composed of tannic acid (TA)-modified chitosan (CS) and 4-carboxyphenylboronic acid (CPBA)-grafted ε-polylysine (EPL), via the integration of dynamic covalent bonds (boronate ester bonds), hydrogen bonds, and multiple noncovalent interactions. This design endows the hydrogel with dual responsiveness to both the acidic and hyperglycemic microenvironments characteristic of diabetic wounds. In vitro assays demonstrated that the hydrogel achieved over 97.0% scavenging rates against both DPPH and ABTS radicals, and exhibited antibacterial rates of up to 99.0% against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus, along with excellent cytocompatibility. In addition, in a streptozotocin (STZ)-induced diabetic rat wound model, the wound closure rate reached 97.9% by day 14. Histological analyses further confirmed that the dressing might adapt to the diabetic wound microenvironment, which could help re-epithelialization of the injured wounds and restoration of epidermal thickness to near physiological levels. This multifunctional hydrogel offers a promising strategy for diabetic wound repair research. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acsapm.6c02832.s001 https://figshare.com/articles/journal_contribution/A_pH_and_Glucose_Dual-Responsive_Injectable_Chitosan_-Polylysine_Hydrogel_with_Inherent_Antibacterial_and_Antioxidant_Activities_for_Diabetic_Wound_Healing/34041417 CC BY-NC 4.0