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oai:figshare.com:article/34041299 2026-10-01T07:25:02Z category_37339 category_37354 category_37366 portal_1012 item_type_6 month_year_10_2026

Supplementary Figure 1 from The H63D Polymorphism in the HFE Gene Promotes Aggressive Disease Phenotypes in Pancreatic Ductal Adenocarcinoma Federica Rubbino (25155083) Luana Greco (25155086) Alessandro Scagliotti (25155089) Alessio Di Cristofaro (25155092) Valentina de Murtas (25155095) Gabriele De Simone (25155098) Stefania Forciniti (25155101) Fabio Grizzi (15125329) Paolo Bianchi (25155104) Gianluca Basso (15137545) Luca Lambroia (25155107) Paolo Kunderfranco (15137566) Paola Cappello (15089919) Francesco Novelli (25155110) Claudio Doglioni (25155113) Piergiuseppe Colombo (25155116) Massimiliano Mazzone (15136493) Massimo Falconi (25155119) Alessandro Zerbi (24694352) Alberto Malesci (25155122) Luigi Laghi (25155125) Cancer Molecular and Cellular Biology Clinical Research and Trials Cell Cycle Control of cell cycle progression Gastrointestinal Cancers Pancreatic cancer Precision Medicine (A) Agarose gel electrophoresis showing representative PCR amplicons for the indicated genotypes. The lanes correspond to different mouse samples with combinations of KrasLSL.G12D/+, HfeH67D/H67D, and Pdx1-Cre alleles. Molecular weight markers (in base pairs) are shown on the left. (B) Representative summary table of genotypes analyzed, including presence or absence of the KrasLSL.G12D/+, Pdx1-Cre, and various Hfe alleles (+/−, +/+, or −/−). (C) Representative flow cytometry histograms of CFP fluorescence intensity (CFP-A) for the assessment of cell population synchronization. Peak alignment and distribution dispersion indicate the degree of synchronization. Colored overlays denote cell cycle phases: G1 (purple), S (yellow), and G2 (green). Data are representative of independent biological replicates. 2026-10-01T00:00:00Z Text Journal contribution 10.1158/1078-0432.34041299 https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_The_H63D_Polymorphism_in_the_i_HFE_i_Gene_Promotes_Aggressive_Disease_Phenotypes_in_Pancreatic_Ductal_Adenocarcinoma/34041299 CC BY