2026-10-07T09:27:04Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34040951 2026-10-01T07:22:14Z category_37339 category_37351 category_37360 category_37375 portal_1012 item_type_6 month_year_10_2026

Supplementary Figures S1-S15 from A Spatial Atlas of Muscle-Invasive Bladder Cancer Reveals Lineage-Specific Vulnerabilities and Immune Architecture Kai Yu (24230305) Jianfeng Chen (19817615) Yu-Yi Chu (25154564) Sajith Nair (25154567) Emanuele Crupi (15051287) Elshad Hasanov (17079613) Ying Mei (25154570) Xueshuai Han (25154573) Yang Liu (25154576) Yunhe Liu (25154579) Guangsheng Pei (15038747) Fuduan Peng (20374578) Jianlong Liao (25154582) Enyu Dai (15122562) Tian Chu (25154585) Kyung Serk Cho (25154588) Jiahui Jiang (25154591) Xinmiao Yan (23273574) Yibo Dai (19274873) Jun Wang (25154594) Baifeng Zhang (25154597) Giannicola Genovese (20887543) Nagireddy Putluri (15049254) Livia Eberlin (25154600) Liuqing Yang (24230566) Chunru Lin (11351576) Lawrence N. Kwong (15393697) Diana Shamsutdinova (24227312) Khalida M. Wani (15049272) Bogdan A. Czerniak (25154603) Wendong Yu (25154606) Jianping Zhao (25154609) Charles C. Guo (19686183) Donna Hansel (25154612) Curtis Pettaway (25154615) Louis Pisters (25154618) Kelly Bree (25154621) Neema Navai (19686174) Byron H. Lee (14963189) Ashish M. Kamat (19686171) Padmanee Sharma (17091431) Paul Corn (25154624) Cindy Y. Jiang (25154627) Amishi Y. Shah (19686165) Omar Alhalabi (15096425) Pavlos Msaouel (15096428) Arlene O. Siefker-Radtke (19686168) Christopher J. Logothetis (14957643) Matthew T. Campbell (15096440) Alexander J. Lazar (14963562) Jianjun Gao (19817618) Linghua Wang (15116437) Cancer Tumor Biology Therapeutic Research and Development Methods and Technology Chemotherapy Genitourinary Cancers Bladder cancer Single Cell Technologies Single-cell RNA Sequencing (scRNA-seq) Tumor Heterogeneity Tumor Microenvironment <p>Supplementary Figures file contains Supplementary Figures S1–S15. Figure S1 | Pathology-guided spatial annotation across 22 MIBC tumors. Figure S2 | Validation of spatial deconvolution accuracy and cell-type compartmentalization. Figure S3 | Additional tumors demonstrating spatial CNV-based subclones and transcriptional divergence. Figure S4 | Cross-platform concordance of CNV profiles inferred from spatial transcriptomics and WES. Figure S5 | Transcriptional and functional features across the luminal-to-basal differentiation continuum. Figure S6 | Single-cell analysis recapitulates the spatial luminal-to-basal differentiation continuum. Figure S7 | Spatial validation of lineage-associated EGFR and FGFR3 expression patterns. Figure S8 | Lineage-associated expression of FGFR3–EGFR signaling and transcriptional regulators across normal tissue, tumor states, and independent cohorts. Figure S9 | Pathology-guided spatial annotation across all MIBC tumors. Figure S10 | Spatial tumor states associate with chemotherapy response and stress-related gene expression. Figure S11 | NECTIN4 expression is enriched in luminal tumors and declines at the tumor-normal boundary. Figure S12 | Subtype-associated genomic alterations and their relationship with basal program activity. Figure S13 | Associations between basal signature scores and clinical or molecular features across MIBC cohorts. Figure S14 | Pathologist-guided TLS annotation confirms spatial transcriptomic predictions. Figure S15 | Lineage-associated chemokine programs and tumor–TLS interactions.</p> 2026-10-01T00:00:00Z Text Journal contribution 10.1158/2159-8290.34040951 https://figshare.com/articles/journal_contribution/Supplementary_Figures_S1-S15_from_A_Spatial_Atlas_of_Muscle-Invasive_Bladder_Cancer_Reveals_Lineage-Specific_Vulnerabilities_and_Immune_Architecture/34040951 CC BY