2026-10-12T23:25:51Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34040940 2026-10-01T07:22:03Z category_37339 category_37354 category_37360 category_37366 portal_1012 item_type_1 month_year_10_2026

Figure 2 from Circadian Genotypes in PER3 and Time of Prostate Cancer Radiotherapy Interact to Affect Risk of Late Side Effects Adam J. Webb (21234554) Emily Harper (25154469) Tim Rattay (25154472) Miguel E. Aguado-Barrera (21234560) Barbara Avuzzi (22751724) Renée Bultijnck (25154475) Ananya Choudhury (20432579) Dirk K. De Ruysscher (25154478) Olivia Fuentes-Ríos (16547433) Sara Gutiérrez-Enríquez (14956044) Sarah L. Kerns (21234605) Ramón Lobato-Busto (25154481) Alan McWilliam (22751742) Barbara Noris Chiorda (25154484) Tiziana Rancati (21234536) Barry S. Rosenstein (21234575) Petra Seibold (21234542) Elena Sperk (21234545) Ana Vega (16547559) Liv Veldeman (21234551) Tim H. Ward (25154487) Catharine M. West (25154490) Paul Symonds (25154493) Christopher J. Talbot (21234548) Rita Aerts (25154496) Soumia Arredouani (25154499) David Azria (8437) Celine Bourgier (839076) Muriel Brengues (7184183) Erik Briers (19695517) Patricia Calvo-Crespo (22890182) Ana Carballo (25154502) Angel Carracedo (3123957) Jenny Chang-Claude (23562) Ana Crujeiras González (25154505) Wilfried De Neve (808061) Gilles Defraene (3210708) Pieter Deseyne (25154508) Hannah Dobbelaere (25154511) Isabel Dominguez-Rios (25154514) Roxana Draghici (13263909) Alison Dunning (10539) Fréderic Duprez (3513314) Michael Ehmann (25154517) Elhaseen Elhamin (25154520) Rebecca M. Elliott (9522692) Vicki Emms (7799753) Laura Fachal (171665) Corinne Faivre-Finn (4334800) Irene Fajardo-Paneque (25154523) Marie-Pierre Farcy-Jacquet (20725628) Juan Fernández-Tajes (6517655) Valérie Fonteyne (837666) Marzia Franceschini (9240604) Benjamin Gauter-Fleckenstein (25154526) Frank Giordano (6813485) Alexandra Giraldo (25154529) Antonio Gómez-Caamaño (11480689) Karin Haustermans (757212) Irmgard Helmbold (23557) Carsten Herskind (512441) Philipp Heumann (16825530) Kerstie Johnson (9522683) Maarten Lambrecht (5526458) Samuel Lavers (25154532) Yolande Lievens (808058) Marcus Mareel (25154535) Monserrat Miranda Currás (25154538) Meritxell Mollà (15112493) Christel Monten (24896476) Anusha Müller (20725643) Piet Ost (837668) Leen Paelinck (808057) Stephanie Peeters (3210717) Paula Peleteiro (25154541) Giselle Post (9507171) Mónica Ramos (18058771) Belinda Rodríguez-Lage (25154544) Paloma Sosa-Fajardo (25154547) Hilary Stobart (10971060) Martijn Swimberghe (25154550) Begoña Taboada-Valladares (24896479) Laura Torrado-Moya (25154553) Marc van Eijkeren (4387366) Annick Van Greveling (9507174) Erik van Limberghen (25154556) Katrien Vandecasteele (808062) Ben Vanneste (6946307) Marlon Veldwijk (3685954) Tom Vercauteren (3409862) Caroline Weltens (553708) Cancer Molecular and Cellular Biology Therapeutic Research and Development Clinical Research and Trials Genitourinary Cancers Prostate cancer Genome Biology Precision Medicine Radiation Oncology Radiation-induced late effects A, Predicted probability (y-axis) of a patient developing late RB (top row) and late UI (second row) as derived from fixed-effects regression models for different treatment times (solar time of day, x-axis) and genotype for VAMP3 SNP rs11121022 and adjacent PER3 SNP rs172933, rs696305, rs35128310, rs488728, rs288640, and rs697689. Probabilities of developing each late side effect are given for patient groups grouped by genotype at each SNP. Possible patient genotypes are colored as follows: purple, homozygous for allele 1; green, heterozygous; yellow, homozygous for allele 2. Alleles are arbitrarily assigned as allele 1 or allele 2, and their assignments can be determined from B. Shaded areas show 95% CI for predictions. B, Proportion of patients in the study cohort (European population) with given genotypes for each SNP. Colors represent genotypes for homozygous alleles 1/1 (purple), heterozygotes (green), and homozygous allele 2 (yellow). Actual SNP alleles are provided in the text labels along with the expected proportion of patients with those genotypes according to population frequency estimates. C, Chromosome diagram showing the position of each SNP on chromosome 1 (GRCh38). The position of PER3 VNTR rs57875989 is shown in exon 18. Gene structures of VAMP3 and PER3 are shown beneath. 2026-10-01T00:00:00Z Image Figure 10.1158/1078-0432.34040940 https://figshare.com/articles/figure/Figure_2_from_Circadian_Genotypes_in_i_PER3_i_and_Time_of_Prostate_Cancer_Radiotherapy_Interact_to_Affect_Risk_of_Late_Side_Effects/34040940 CC BY