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oai:figshare.com:article/34040886 2026-10-01T07:21:40Z category_37339 category_37351 category_37363 portal_1012 item_type_6 month_year_10_2026

Supplementary Figures S1-S17 from LPL-Positive Endothelial Cells Control T-cell Homing in Liver Metastasis Xiaowen Zhang (25154451) Miki Kamiyama (25154454) Margaret Tulessin (25154457) Lorna Rinck (25154460) Jan-Philipp Mallm (23329315) Michael Kilian (16697663) Dennis A. Agardy (19458017) Mathias Heikenwälder (25154463) Michael Platten (15018165) Carolin Mogler (25154466) Mahak Singhal (14939099) Hellmut G. Augustin (14939117) Cancer Tumor Biology Immuno-oncology Immunology Immune responses to cancer Progression, Invasion & Metastasis Tumor Microenvironment Immune cells and the microenvironment <p>Supplementary figures S1-S17 and their figure legends. Figure S1. Endothelial cells regulate effector T cell homing in OVA-B16F10 liver metastases. Figure S2. Quality control of scRNAseq data of all analyzed ECs. Figure S3. Changes in the cluster composition of analyzed ECs following ACT. Figure S4. Annotation of different tumor EC subsets. Figure S5. scRNAseq-guided molecular characterization of TECs. Figure S6. Genetic deletion of Lpl in ECs and its influence on intratumoral vessels. Figure S7. Genetic overexpression of Lpl in ECs and its influence on intratumoral vessels. Figure S8. Effect of endothelial LPL on OT-I T cell infiltration in the OVA-LLC liver metastatic model. Figure S9. Single-cell characterization of the immune landscape of liver metastatic tumors with endothelial LPL intervention. Figure S10. Characterization of tumor-associated monocytes/macrophages with EC-LPL intervention. Figure S11. Characterization of intratumoral CD8+ T cells with EC-LPL intervention. Figure S12. Endothelial LPL upregulation results in the activation of molecules related to MHC-I-mediated antigen presentation. Figure S13. In vivo MHC-I blocking experiment. Figure S14. Endothelial antigen presentation facilitates T cell infiltration into liver metastatic tumors. Figure S15. Analysis of EC death after ACT of activated OT-I T cells. Figure S16. Assessment of LPL+ TECs in clinically relevant intervention models. Figure S17. Staining of LPL on human CRC-derived liver metastatic tumor tissue.</p> 2026-10-01T00:00:00Z Text Journal contribution 10.1158/2159-8290.34040886 https://figshare.com/articles/journal_contribution/Supplementary_Figures_S1-S17_from_LPL-Positive_Endothelial_Cells_Control_T-cell_Homing_in_Liver_Metastasis/34040886 CC BY