2026-10-12T09:07:54Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34040792 2026-10-01T07:20:55Z category_37339 category_37354 portal_1012 item_type_6 month_year_10_2026

Supplementary Figures S1-S6 from Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia Juliano Machado (25154222) Vignesh Karthikaisamy (25154225) Hermine Mohr (25154228) Doris Kaltenecker (25154231) Pia Benedikt (25154234) Pauline Morigny (25154237) Amit Mhamane (25154240) Julia Geppert (25154243) Amy Rose Fumo (25154246) Kerstin Haase (14123058) Estefania Simoes (25154249) Joanna D.C.C. Lima (18725115) Anastasia Georgiadi (25154252) Achim Krüger (25154255) José Pinhata Otoch (25154258) Marc E. Martignoni (25154261) Vickie E. Baracos (25154264) Mariam Jamal-Hanjani (15386766) Marilia C.L. Seelaender (25154267) Olga Prokopchuk (25154270) Julia Szendrödi (25154273) Maria Rohm (25154276) Stephan Herzig (25154279) Mauricio Berriel Diaz (15037094) Cancer Molecular and Cellular Biology Gastrointestinal Cancers Colorectal cancer Lung Cancer Metabolism Metabolic pathways <p>Supplementary Fig. S1. ADAMTSL4 is enriched in conditioned media of cachexia-inducing cancer cell lines and is associated with systemic metabolic alterations in patients with cancer. Supplementary Fig. S2. Overexpression of ADAMTSL4 converts non-cachexia-inducing cells into cachexia-inducing cells. Supplementary Fig. S3. Stable knockdown of ADAMTSL4 in cachexia-inducing cells attenuates their muscle-wasting capacity in vitro. Supplementary Fig. S4. Stable knockdown of ADAMTSL4 in cachexia-inducing tumor cells attenuates in vitro and in vivo adipocyte wasting and prolongs cachexia-related survival. Supplementary Fig. S5. ADAMTSL4 targets LAP of latent TGF-β1 complex to promote myotube atrophy via TGF-β latency activation and TGFβR-dependent signaling. Supplementary Fig. S6. ADAMTSL4 induces wasting of murine and human white adipocytes via local activation of TGF-β1–TGFBR1 signaling, without altering circulating TGF-β1 levels.</p> 2026-10-01T00:00:00Z Text Journal contribution 10.1158/2159-8290.34040792 https://figshare.com/articles/journal_contribution/Supplementary_Figures_S1-S6_from_Tumor-Secreted_ADAMTSL4_Activates_Latent_TGF_1_to_Drive_Cancer_Cachexia/34040792 CC BY