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oai:figshare.com:article/34040601 2026-10-01T07:07:10Z category_1 category_4 category_7 category_8 category_12 category_13 category_14 category_16 category_46 category_734 category_64 category_122 category_132 category_135 portal_63 item_type_6 month_year_10_2026

Proteomic Profiling Identifies Infection-Associated Pathways in Pediatric Aortic Aneurysms Hai-Qun Shi (25153743) Jun-Jie Ao (25153746) Yu-Fan Ke (25153749) Ke Cai (220190) Xin Sun (127355) Rui Zhao (43391) Wei-Cheng Chen (9433) Jian-Yuan Zhao (181244) Yan Shi (166398) Biophysics Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Physiology Immunology Biological Sciences not elsewhere classified Cancer Mental Health Infectious Diseases Computational Biology representative actin cytoskeleton providing novel insights extracellular matrix remodeling conducted nanoliquid chromatography compare protein differences actin cytoskeleton organization innate immune signaling suggesting structural alterations may reflect activation including increased expression aortic tissue samples pediatric aa development better understand aa associated immune pathways suggesting activation immune dysregulation associated pathways decreased expression aortic wall related pathways associated proteins aa patients threatening condition related proteins proteins involved potential involvement findings highlight direct evidence aneurysm formation Aortic aneurysm (AA) in children is a rare but life-threatening condition with poorly understood molecular mechanisms. To better understand AA in children, we conducted nanoliquid chromatography-tandem mass spectrometry analysis to compare protein differences in aortic tissue samples between AA patients and controls. Our proteomic analysis revealed significant enrichment of infection-associated immune pathways, accompanied by the upregulation of PRMT1, RIG-I, ISG15, and STING1, suggesting activation of innate immune signaling during pediatric AA development. Pathway enrichment analysis identified multiple pathways annotated as bacterial- and viral infection-related pathways, which may reflect activation of innate immune signaling or sterile inflammatory responses rather than direct evidence of active infection. Furthermore, proteomic profiling identified dysregulation of proteins involved in actin cytoskeleton organization and extracellular matrix remodeling, including increased expression of representative actin cytoskeleton-associated proteins and decreased expression of collagen-related proteins, suggesting structural alterations of the aortic wall. Collectively, these findings highlight the potential involvement of infection-associated innate immune signaling and immune dysregulation, providing novel insights into the molecular mechanisms underlying vascular remodeling and aneurysm formation. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acs.jproteome.6c00149.s001 https://figshare.com/articles/journal_contribution/Proteomic_Profiling_Identifies_Infection-Associated_Pathways_in_Pediatric_Aortic_Aneurysms/34040601 CC BY-NC 4.0