2026-10-13T11:26:23Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34040535 2026-10-01T06:42:53Z category_25198 portal_21 item_type_8 month_year_10_2026

Directing Drug Exposure of Novel Drug Agents Targeting the CNS and Gut for Improved Efficacy and Safety Kin Bong Kelvin Chu (25153686) Medicinal and biomolecular chemistry not elsewhere classified Inflammatory Bowel Disease IBD Crohn's Disease Ulcerative Colitis Pharmacokinetics Biodistribution In Vivo GI-Restriction Controlling the biodistribution of drug molecules through chemical design, even at the cost of potency, offers significant advantages in both safety and efficacy by limiting off-target toxicities or increasing drug exposure in the target tissue. This thesis focuses on the localised delivery of chemically modified drug candidates for the treatment of inflammatory bowel disease, including ulcerative colitis and Crohn's disease. In this effort, we have identified three potent gut-restricted ALK5 inhibitors that are suitable to pursue further analysis in disease models.<p></p> 2026-10-01T06:42:53Z Text Thesis 10.26180/34040535.v1 https://figshare.com/articles/thesis/Directing_Drug_Exposure_of_Novel_Drug_Agents_Targeting_the_CNS_and_Gut_for_Improved_Efficacy_and_Safety/34040535 In Copyright Embargoed