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oai:figshare.com:article/34039704 2026-10-01T05:43:20Z category_320 portal_316 item_type_3 month_year_10_2026

Table 1_Effect of metformin treatment on brain 18F-FDG uptake: a translational study.docx Rubén Fernández de la Rosa (25153059) Gonzalo Cuesta Domingo (25153062) Pedro Nespral (17399188) Elena Marcos-Macías (25153065) Marta Vaillant (25153068) Luis García-García (25153071) Miguel Ángel Pozo (25153074) Jordi A. Matias-Guiu (5572424) María Nieves Cabrera-Martin (25153077) Mirjam Brackhan (20626217) Pablo Bascuñana (11752076) Radiology and Organ Imaging diabetes metformin neurodegeneration neuroimaging PET Introduction<p>Metformin is one of the most widely used drugs to control diabetes type 2. However, there is no indication of pausing metformin treatment before an ¹⁸F-FDG PET scan. The aim of this study is to evaluate if metformin, in both patients and mice, can alter brain ¹⁸F-FDG uptake.</p>Methods<p>In vivo¹⁸F-FDG PET scans were carried out in male mice. Animals were treated with saline or metformin (300 mg/kg) 10 min before ¹⁸F-FDG or chronically (3 weeks) in drinking water. Separately, patients with non-pathological ¹⁸F-FDG brain scans were distributed into two groups: metformin-treated (n = 12) and control patients (n = 27). PET images were structurally normalized to brain templates, corrected to whole-brain activity, and compared using SPM12.</p>Results<p>In mice, acute treatment induced a significant hypermetabolism in several brain regions including hippocampus (1.07 ± 0.07 vs 0.94 ± 0.08; p = 0.0002) and thalamus (1.17 ± 0.08 vs 1.00 ± 0.08; p = 0.0002). Chronic treatment increased tracer uptake only in cortical regions. Similarly, treated patients showed hypermetabolism in the temporal lobe (1.03 ± 0.04 vs 0.97 ± 0.04; p < 0.0001) and white matter and lower uptake in frontal cortical regions (1.24 ± 0.04 vs 1.28 ± 0.06; p = 0.0165). Linear regression to HbA1c showed a negative correlation to ¹⁸F-FDG uptake in frontal and parietal cortical subregions, but no correlation to temporal lobe uptake.</p>Discussion<p>Our results show that metformin treatment might modify ¹⁸F-FDG uptake in temporal lobe structures. On the other hand, lower uptake in frontal cortex might be attributable to the diabetic condition. Thus, new studies modifying the treatment regimen in diabetic patients prior to performing an ¹⁸F-FDG PET are warranted.</p> 2026-10-01T05:43:20Z Dataset Dataset 10.3389/fradi.2026.1917175.s002 https://figshare.com/articles/dataset/Table_1_Effect_of_metformin_treatment_on_brain_18F-FDG_uptake_a_translational_study_docx/34039704 CC BY 4.0