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oai:figshare.com:article/34039164 2026-10-01T05:29:38Z category_13 portal_316 item_type_3 month_year_10_2026

Data Sheet 1_A pilot genome-wide association study of ischemic heart disease with co-occurring arterial hypertension in a Kazakh cohort.docx Liliya Skvortsova (11917508) Kanagat Yergali (21992102) Assel Zhaxylykova (21992096) Mamura Begmanova (11917529) Almagul Mansharipova (25152546) Genetics arterial hypertension Central Asia genome-wide association study ischemic heart disease Kazakh population ZFHX3 Background<p>Genome-wide association studies (GWAS) of ischemic heart disease (IHD) remain underrepresented in Central Asian populations. We conducted a pilot GWAS of ischemic heart disease with co-occurring arterial hypertension (IHD-HTN) in an ethnic Kazakh cohort to identify candidate loci for future replication.</p>Methods<p>This study included 470 Kazakh individuals, comprising of 240 cases and 230 controls genotyped using the Illumina Infinium Global Screening Array-24 v 3.0. Association testing was performed using logistic regression under an additive genetic model adjusted for age, sex, and the first 10 principal components. Post-imputation GWAS was performed using high-quality imputed variants. Secondary analyses included MAGMA and KGWAS prioritization.</p>Results<p>In the array-based GWAS, no variant reached the Bonferroni-corrected significance threshold (P < 1.53 × 10⁻⁷). The strongest SNP association was observed for rs1511924 at chromosome 16 mapped to the ZFHX3 gene (OR = 0.49, 95% CI = 0.37–0.66; P = 1.00 × 10⁻⁶). Post-imputation GWAS supported the same locus with rs12598508 (P = 4.93 × 10⁻⁷) and rs1511924 (P = 5.15 × 10⁻⁷) among the strongest signals, although neither reached the genome-wide significance. Secondary MAGMA and KGWAS analyses did not provide stable evidence for additional loci.</p>Conclusion<p>To our knowledge, this is the first pilot GWAS focused on IHD with co-occurring arterial hypertension in a Kazakh cohort. Although no Bonferroni-significant SNP associations were identified, the ZFHX3 region emerged as the strongest suggestive candidate locus and requires independent replication. Larger Central Asian cohorts and population-specific reference resources are required to validate these findings.</p> 2026-10-01T05:29:38Z Dataset Dataset 10.3389/fgene.2026.1927147.s002 https://figshare.com/articles/dataset/Data_Sheet_1_A_pilot_genome-wide_association_study_of_ischemic_heart_disease_with_co-occurring_arterial_hypertension_in_a_Kazakh_cohort_docx/34039164 CC BY 4.0