2026-10-10T06:29:49Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34039125 2026-10-01T05:29:22Z category_393 portal_316 item_type_3 month_year_10_2026

Table 1_Underwater hybrid ESD versus conventional ESD for colorectal laterally spreading tumors: a retrospective study.docx Qirun Cheng (17545868) Yu-liang Feng (25152477) Li-peng Chen (25152480) Foetal Development and Medicine colorectal neoplasms hybrid endoscopic submucosal dissection laterally spreading tumors R0 resection underwater endoscopic submucosal dissection Background and aims<p>Conventional endoscopic submucosal dissection (C-ESD) is standard for colorectal laterally spreading tumors (LSTs) but is time-consuming. Underwater hybrid ESD (U-Hybrid ESD) is an emerging technique. We compared the efficacy and safety of U-Hybrid ESD versus C-ESD for colorectal LSTs.</p>Methods<p>This exploratory, single-center retrospective study included 300 patients with LSTs ≥20 mm (U-Hybrid ESD, n = 150; C-ESD, n = 150). Procedure time, postoperative hospital stay, time to resume oral diet, R0 resection rate, and adverse events were compared. Hypothesis-generating stratified analyses by lesion size and pathology were also performed.</p>Results<p>After multivariable adjustment, U-Hybrid ESD had significantly shorter procedure time (adjusted mean 21.29 vs. 31.99 min, adjusted mean difference −10.70, P < 0.001), shorter hospital stay (2.38 vs. 2.61 days, P = 0.008), and earlier oral diet (25.28 vs. 28.32 h, P = 0.004). The R0 resection rate showed a numerical difference between groups (96.67% vs. 100%), which did not reach statistical significance on Fisher's exact test (P = 0.060). Adverse events did not differ significantly (5.33% vs. 9.33%, P = 0.318).</p>Conclusions<p>In this exploratory analysis, U-Hybrid ESD was associated with shorter procedure time and modest improvements in postoperative recovery metrics, without a significant increase in complications. These hypothesis-generating findings suggest that U-Hybrid ESD may offer efficiency benefits for selected lesions, but the potential trend toward lower R0 rates for large or high-grade lesions warrants caution and prospective validation before any definitive size-based recommendations can be made.</p> 2026-10-01T05:29:22Z Dataset Dataset 10.3389/fmed.2026.1942087.s001 https://figshare.com/articles/dataset/Table_1_Underwater_hybrid_ESD_versus_conventional_ESD_for_colorectal_laterally_spreading_tumors_a_retrospective_study_docx/34039125 CC BY 4.0