2026-10-14T05:53:13Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34039033 2026-10-01T05:08:48Z category_146 category_21 category_24 category_272 category_873 category_39 category_128 portal_63 item_type_6 month_year_10_2026

Fluorocarbon Architecture Tuning Enables Superior Platelet Adhesion Resistance in Medical Polyurethane with Limited Change in Apparent Surface Hydrophobicity Linglong Zhou (25152355) Xiaohan Yang (430728) Yuanshu Zhao (25152358) Haoyuan Zhu (19816033) Wei Qiang (458848) Guodong Ye (7311869) Xin Li (51274) Jing Zhao (21160) Yugang Huang (784468) Space Science Biotechnology Evolutionary Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Ecology Hematology surface fluorine content ray photoelectron spectroscopy potentially useful component molecular design space induced surface hydrophobicity covarying molecular weight apparent surface hydrophobicity fpup35 – 5 5 also exhibited 0 reduced long including nominal fluorocarbon different nominal fluorocarbon overall fpup architecture l929 adhesion ratio resistant pu surfaces biomedical pu matrix fpup35 – 7 nominal fluorocarbon fpup35 exhibited fpup architecture pu matrix reduced activation fluorinated surfaces term fibrinogen substantial differences site density site densities simply correlate separate monocultures segment composition results indicate qualitatively consistent often attributed medical polyurethane limited changes limited change fluorinated polyurethane biointerfacial performance 69 %, 24 h The improved platelet adhesion resistance of fluorinated polyurethane (PU) is often attributed to the fluorination-induced surface hydrophobicity. Here, we show that superior platelet adhesion resistance can be achieved with limited changes in the apparent surface hydrophobicity as well. Dual-anchored fluorinated polyurethane prepolymers (FPUPs) with different nominal fluorocarbon-site densities were synthesized and blended with a biomedical PU matrix. X-ray photoelectron spectroscopy (XPS) showed that the surface fluorine content varied from 8.7 to 37.3% across the formulations, whereas most films exhibited static water contact angles comparable to the value for the PU matrix. Thus, variations in the FPUP architecture were associated with substantial differences in surface composition without proportional changes in the static water contact angle. Among the tested formulations, FPUP35 exhibited the most favorable overall biointerfacial performance: FPUP35–5.0 reduced long-term fibrinogen (Fib) adsorption by 44.4%; FPUP35–2.5 reduced platelet adhesion density by 69%, and platelet morphologies on the fluorinated surfaces were qualitatively consistent with reduced activation-associated spreading; FPUP35–7.5 also exhibited an HUVEC/L929 adhesion ratio of 1.85 after 24 h in separate monocultures. These results indicate that biointerfacial performance does not simply correlate with surface fluorine content but is associated with overall FPUP architecture, including nominal fluorocarbon-site density and covarying molecular weight and segment composition. Nominal fluorocarbon-site density is therefore a potentially useful component of the molecular design space for platelet-adhesion-resistant PU surfaces. 2026-10-01T00:00:00Z Text Journal contribution 10.1021/acsapm.6c03324.s001 https://figshare.com/articles/journal_contribution/Fluorocarbon_Architecture_Tuning_Enables_Superior_Platelet_Adhesion_Resistance_in_Medical_Polyurethane_with_Limited_Change_in_Apparent_Surface_Hydrophobicity/34039033 CC BY-NC 4.0