2026-10-12T07:31:32Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34038063 2026-10-01T04:24:34Z category_374 portal_316 item_type_3 month_year_10_2026

Table 1_Dietary intake and circulating levels of vitamins, antioxidants, and fatty acids in relation to coronary heart disease risk: a systematic review and dose–response meta-analysis.docx Peng Tian (119465) Chang Su (170990) Yang Yang (45629) Zhao Su (17698764) Mengrou Gao (25151571) Xiangru Tan (25151574) Qiuyan Zhang (6567023) Clinical and Sports Nutrition antioxidants coronary heart disease dose–response meta-analysis fatty acids systematic review vitamins Background<p>Associations between vitamin, antioxidant, and fatty acid exposure and coronary heart disease (CHD) risk remain uncertain, and dose–response relationships are poorly defined. This study aimed to evaluate the overall and dose–response associations between dietary and circulating vitamin, antioxidant, and fatty acid levels and CHD risk from observational evidence.</p>Methods<p>PubMed, Web of Science, Embase, and the Cochrane Library were searched for studies published up to February 2, 2026 (PROSPERO: CRD420261380823). Eligible observational studies (case–control, cohort, cross-sectional) reporting associations between vitamin, antioxidant, or fatty acid levels and CHD risk were included. A total of 27 studies were analyzed. Categorical (highest vs. lowest) and dose–response analyses were performed, estimating pooled odds ratios (ORs), relative risks (RRs), and hazard ratios (HRs).</p>Results<p>Twenty-seven observational studies were included. In categorical analyses, higher circulating 25(OH)D (pooled HR = 0.79, 95% CI = 0.74–0.85; I² = 1.4%, τ² = 0.0000) and carotenoids (pooled OR = 0.64, 95% CI = 0.46–0.91; I² = 0.0%, τ² = 0.0000) were inversely associated with CHD risk. In analyses per 1-SD increase in circulating fatty acid levels, linoleic acid was inversely associated with CHD risk (pooled OR = 0.69, 95% CI = 0.57–0.84; I² = 0.0%, τ² = 0.0000), whereas palmitic acid (pooled OR = 1.52, 95% CI = 1.23–1.89; I² = 0.0%, τ² = 0.0000) and dihomo-γ-linolenic acid (DGLA; pooled OR = 1.26, 95% CI = 1.05–1.52; I² = 0.0%, τ² = 0.0000) were positively associated with CHD risk. Several other exposure-specific estimates and most dose–response analyses were supported by only one or two studies and should therefore be interpreted cautiously.</p>Conclusion<p>In observational studies, selected dietary and circulating vitamin, antioxidant, and fatty acid exposures were associated with CHD risk. These associations do not establish causality or justify specific supplementation recommendations, and findings based on sparse data require confirmation in additional prospective studies.</p> 2026-10-01T04:24:34Z Dataset Dataset 10.3389/fnut.2026.1920716.s001 https://figshare.com/articles/dataset/Table_1_Dietary_intake_and_circulating_levels_of_vitamins_antioxidants_and_fatty_acids_in_relation_to_coronary_heart_disease_risk_a_systematic_review_and_dose_response_meta-analysis_docx/34038063 CC BY 4.0