2026-10-13T17:07:34Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34037680 2026-10-01T01:48:22Z category_7 category_21 category_46 category_64 category_106 portal_87 item_type_6 month_year_10_2026

Hepatic arterial infusion chemotherapy plus lenvatinib with or without PD-1 inhibition for unresectable hepatocellular carcinoma: a retrospective cohort study Haidong Yu (101810) Cunkai Ma (25147522) Cairang Yangdan (25147525) Haiming Yang (11192941) Xiaolei Xu (81386) Medicine Biotechnology Immunology Cancer Science Policy Hepatic arterial infusion chemotherapy lenvatinib PD-1 inhibition unresectable hepatocellular carcinoma propensity score matching retrospective study <p>The benefit of adding programmed cell death protein 1 (PD-1) blockade to hepatic arterial infusion chemotherapy (HAIC) plus lenvatinib for unresectable hepatocellular carcinoma remains uncertain. This single-center retrospective cohort study included 373 patients. After propensity score matching, 107 patients treated with HAIC plus lenvatinib alone and 107 patients treated with a PD-1 inhibitor were analyzed. Outcomes included overall survival (OS), progression-free survival (PFS), tumor response, and adverse events. PD-1 therapy was associated with longer OS (median, 22.5 vs 13.8 months; adjusted hazard ratio, 0.61; 95% CI, 0.40–0.94; <i>p</i> = 0.025) and a higher objective response rate (52.3% vs 40.2%, <i>p</i> = 0.075). The adjusted PFS difference was significant (hazard ratio, 0.67; 95% CI, 0.48–0.92; <i>p</i> = 0.015). No statistically significant differences in survival were detected among sintilimab, camrelizumab, and pembrolizumab. Grade 3–4 adverse events were comparable. Adding PD-1 blockade was associated with longer OS without substantially increasing severe toxicity.</p> 2026-10-01T01:48:22Z Text Journal contribution 10.6084/m9.figshare.34037680.v1 https://figshare.com/articles/journal_contribution/Hepatic_arterial_infusion_chemotherapy_plus_lenvatinib_with_or_without_PD-1_inhibition_for_unresectable_hepatocellular_carcinoma_a_retrospective_cohort_study/34037680 CC BY 4.0