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Homoisoflavanones,
Alkaloid, and Norsesquiterpenoid
from Polygonatum cyrtonema and Their
Immunomodulatory Effects
Hongsu Zhao (18131829)
Caixia Lu (1849879)
Fucai Ren (16907440)
Xiaoxiao Wei (2131249)
Tongsheng Wang (13908525)
Wuxi Zhou (22453684)
Deling Wu (12325259)
Fengqing Xu (5070899)
Renzhong Wang (312165)
Biochemistry
Pharmacology
Environmental Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
Ecology
Sociology
Biological Sciences not elsewhere classified
Inorganic Chemistry
extensive spectroscopic data
quantum chemical calculations
8 </ b
11 </ b
chemical investigation
widely used
polygonatum cyrtonema
including nmr
huang jing
cultivated p
concentrations ranging
calculated ecd
7 macrophages
25 μm
Polygonatum cyrtonema (Huang
jing)
is widely used in both the food and traditional Chinese medicine industries.
A chemical investigation of the rhizome of cultivated P. cyrtonema yielded six previously undescribed compoundsone
norsesquiterpenoid (<b>1</b>), one pyridine alkaloid (<b>2</b>), and four homoisoflavanones (<b>3a</b>, <b>4a</b>, <b>5a</b>, <b>6a</b>)together with 9 known
compounds (<b>3b</b>, <b>4b</b>, <b>5b</b>, <b>6b</b>, <b>7</b>–<b>11</b>). Their structures
were established on the basis of extensive spectroscopic data and
quantum chemical calculations, including NMR, HRESIMS, and calculated
ECD. The enantiomers of the C-6-methylated homoisoflavanones (<b>3a</b>/<b>3b</b>–<b>6a</b>/<b>6b</b>)
were successfully isolated via chiral HPLC. All compounds were evaluated
for their immunomodulatory activity using RAW264.7 macrophages at
concentrations ranging from 3.125 to 25 μM. Only compounds <b>8</b> and <b>11</b> enhanced the proliferation and phagocytosis
of RAW264.7 macrophages and upregulated the secretion of NO, IL-6,
and TNF-α.
2026-09-30T00:00:00Z
Text
Journal contribution
10.1021/acsomega.6c06988.s001
https://figshare.com/articles/journal_contribution/Homoisoflavanones_Alkaloid_and_Norsesquiterpenoid_from_Polygonatum_cyrtonema_and_Their_Immunomodulatory_Effects/34037498
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