2026-10-14T20:01:49Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34037151 2026-09-30T23:05:13Z category_8 category_12 category_272 category_873 category_39 category_61 category_69 category_133 portal_63 item_type_6 month_year_09_2026

In Situ 3D Crystal Growth Measurement: Unravelling the Nature of Crystal Face-Specific Growth Rate Dispersion in α‑Form l‑Glutamic Acid Chen Jiang (200126) Thomas P. Ilett (18320574) Thomas A. Hazlehurst (18320571) Cai Y. Ma (8490066) David C. Hogg (11216274) Kevin J. Roberts (1348965) Microbiology Cell Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Ecology Developmental Biology Inorganic Chemistry Plant Biology α form l glutamic acid crystals faces growing fastest complex 3d morphology 20 habit faces mass transfer limited local solution environment crystallization process design specific growth rates solution supersaturation limited growth growth process surface integration reflecting differences mechanistic analysis experimental images estimated using enabling calculation density data 6 forms Obtaining 3D crystal morphology and its evolution during growth is beneficial for crystallization process design. A newly developed image analysis tool is used to reconstruct the complex 3D morphology (20 habit faces in 6 forms) of α form l-glutamic acid crystals from 2D transmission microscopy images captured in situ during the growth process. A digital crystallographically based polyhedral mesh is fitted to experimental images, enabling calculation of face-specific growth rates. Solution supersaturation during the growth process is estimated using the fitted crystal volume together with solubility and density data. The data reveals significant growth rate dispersion, reflecting differences in the local solution environment, with {110} and {100} faces growing fastest and {001} the slowest. For our experiments, mechanistic analysis is consistent with surface integration-limited growth, which aligns with the BCF model, except for the {111} and {001} surfaces, which are mass transfer limited under the B&S model. 2026-09-30T00:00:00Z Text Journal contribution 10.1021/acs.iecr.6c02035.s001 https://figshare.com/articles/journal_contribution/In_Situ_3D_Crystal_Growth_Measurement_Unravelling_the_Nature_of_Crystal_Face-Specific_Growth_Rate_Dispersion_in_Form_l_Glutamic_Acid/34037151 CC BY-NC 4.0