2026-10-14T17:14:25Z
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2026-09-30T23:03:38Z
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Silver-Catalyzed
Cascade Reactions for the Synthesis
of Indopyran Pseudo-Natural Products as Potent Anti-tumor Agents
Shuo Yuan (2633836)
Yi-Ru Bai (19998098)
Ruifang Li (312039)
Jian Song (4232)
Ting-Ting Liu (585803)
Sai-Yang Zhang (11324066)
Hong-Min Liu (668537)
Ying Xu (9172)
Biochemistry
Cell Biology
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Cancer
Infectious Diseases
various tumor cells
tumor agents herein
suppressed cell migration
mechanistic studies revealed
effectively arrested cells
catalyzed cascade reactions
3 unique scaffolds
50 </ sub
3t </ b
yield ).
potent anti
natural products
induced apoptosis
indopyran pseudo
including mgc
fused indoles
efficient manner
53 μm
41 examples
Herein, we reported a silver-catalyzed chemoselective
cascade reaction
that enables the synthesis of pyran-fused indoles in an efficient
manner (41 examples, 3 unique scaffolds, up to 93% yield). Compound <b>3t</b> demonstrated potent antiproliferative activity against
various tumor cells, including MGC-803, KYSE-30, and MCF-7, with the
IC<sub>50</sub> values of 5.25, 6.31, and 5.53 μM. The mechanistic
studies revealed that compound <b>3t</b> effectively arrested
cells in the G2/M phase, induced apoptosis, and suppressed cell migration.
2026-09-30T00:00:00Z
Text
Journal contribution
10.1021/acs.orglett.6c03671.s001
https://figshare.com/articles/journal_contribution/Silver-Catalyzed_Cascade_Reactions_for_the_Synthesis_of_Indopyran_Pseudo-Natural_Products_as_Potent_Anti-tumor_Agents/34037142
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