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oai:figshare.com:article/34037067 2026-09-30T22:01:21Z category_19 portal_316 item_type_3 month_year_09_2026

Data Sheet 1_Antispasmodic and analgesic strategies for renal colic in pregnancy: a comprehensive analysis.pdf Bo Lv (549411) Yan Chen (4308) Peiying Huang (6202427) Man Liu (697951) Li Chen (5749) Pharmacology anisodamine phloroglucinol pregnancy progesterone renal colic Background<p>Analgesia remains the paramount priority in the clinical management of gestational renal colic, yet established protocols are frequently constrained by contraindications. While antispasmodic intervention emerges as a viable alternative, the definitive pharmacological choice remains elusive. Here, we evaluated the effectiveness and safety of commonly used antispasmodic and analgesic strategies for pregnancy-related renal colic using network and pairwise meta-analyses.</p>Method<p>A literature review was undertaken utilizing three English-language databases and four Chinese-language databases, encompassing publications up to 1 January 2025. Randomized controlled trials (RCTs) that satisfied the inclusion criteria were selected for analysis. The Cochrane Risk-of-Bias Tool was employed to evaluate the risk of bias. Statistical analyses were performed, encompassing intervention comparison and ranking, assessment of consistency and heterogeneity, evaluation of publication bias, as well as meta-regression, subgroup, and sensitivity analyses.</p>Results<p>The study included ten RCTs with 936 patients. Four dimensions for the RCTs had a low risk of bias, with one dimension having “some concerns.” In network meta-analyses, phloroglucinol was most effective in relieving pain within 1 h, followed by progesterone, while anisodamine was least effective. Phloroglucinol caused the least side effects like nausea and dizziness compared to progesterone and anisodamine. In pairwise meta-analyses, phloroglucinol had a lower 6-h pain recurrence rate and fewer side effects like blurred vision and palpitations than anisodamine. Variations in phloroglucinol dosage contributed to heterogeneity, but subgroup and sensitivity analyses confirmed result stability.</p>Conclusion<p>Phloroglucinol is the preferred treatment for renal colic pain during pregnancy due to its efficacy and safety. It can be combined with progesterone, but anisodamine is not advised. Further high-quality research is necessary to confirm this finding.</p>Clinical Trial Registration<p>https://www.crd.york.ac.uk/PROSPERO/view/CRD42022377502.</p> 2026-09-30T22:01:21Z Dataset Dataset 10.3389/fphar.2026.1758430.s001 https://figshare.com/articles/dataset/Data_Sheet_1_Antispasmodic_and_analgesic_strategies_for_renal_colic_in_pregnancy_a_comprehensive_analysis_pdf/34037067 CC BY 4.0