2026-10-08T00:35:37Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34036819 2026-09-30T20:20:08Z category_13 category_14 category_21 category_24 category_734 category_931 category_64 category_69 portal_5 item_type_1 month_year_09_2026

<p>Reproducibility of model selection across calibration tools.</p> Dilan Pathirana (6292544) Frank T. Bergmann (10036117) Domagoj Doresic (25146007) Polina Lakrisenko (10036138) Sebastian Persson (9241307) Niklas Neubrand (25146010) Jens Timmer (25170) Clemens Kreutz (315828) Harald Binder (39439) Marija Cvijovic (4070044) Daniel Weindl (1844341) Jan Hasenauer (328495) Genetics Molecular Biology Biotechnology Evolutionary Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified Cancer Inorganic Chemistry yield different models parameter estimation problems often competing hypotheses including basic brute g ., akaike existing computational pipelines bayesian information criteria associated calibration problems fair research software model selection tasks model selection problems flexible selection methods petab select introduces petab select builds petab select addresses model selection petab select backward selection sampling methods model alternatives supporting software software package petab standard xlink "> systems biology swift evaluation standard facilitates promoting interoperability one example mathematical modeling first standardization essential contribution ensure flexibility easily extended critical gap compact representation central question broad spectrum biological systems art modelling also advanced <p>Local search methods are the forward (), backward (), and lateral () methods. All calibration tools reproduced the same criterion value in each iteration, within 0.01 AICc. The only difference between tools in each iteration is in the change in selected parameters. is the <i>i</i>th motif-specific parameter; see the Zenodo repository for details.</p> 2026-09-30T18:02:09Z Image Figure 10.1371/journal.pcbi.1014774.g005 https://figshare.com/articles/figure/_p_Reproducibility_of_model_selection_across_calibration_tools_p_/34036819 CC BY 4.0