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oai:figshare.com:article/34036816 2026-09-30T20:20:07Z category_13 category_14 category_21 category_24 category_734 category_931 category_64 category_69 portal_5 item_type_1 month_year_09_2026

<p>Multi-start FAMoS searches solve the Blasi et al. (2016) model selection problem.</p> Dilan Pathirana (6292544) Frank T. Bergmann (10036117) Domagoj Doresic (25146007) Polina Lakrisenko (10036138) Sebastian Persson (9241307) Niklas Neubrand (25146010) Jens Timmer (25170) Clemens Kreutz (315828) Harald Binder (39439) Marija Cvijovic (4070044) Daniel Weindl (1844341) Jan Hasenauer (328495) Genetics Molecular Biology Biotechnology Evolutionary Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified Cancer Inorganic Chemistry yield different models parameter estimation problems often competing hypotheses including basic brute g ., akaike existing computational pipelines bayesian information criteria associated calibration problems fair research software model selection tasks model selection problems flexible selection methods petab select introduces petab select builds petab select addresses model selection petab select backward selection sampling methods model alternatives supporting software software package petab standard xlink "> systems biology swift evaluation standard facilitates promoting interoperability one example mathematical modeling first standardization essential contribution ensure flexibility easily extended critical gap compact representation central question broad spectrum biological systems art modelling also advanced <p><b>(a)</b> An initial model, visualized as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014774#pcbi.1014774.g003" target="_blank">Fig 3a</a>, that was used to initialize one of the FAMoS searches. This is the initial model that was used later to assess reproducibility with all calibration tools. <b>(b)</b> The sizes of models before and after model selection. The published best model had seven motif-specific rate constants. <b>(c)</b> The criterion of the selected model from each of the 100 FAMoS searches.</p> 2026-09-30T18:02:09Z Image Figure 10.1371/journal.pcbi.1014774.g004 https://figshare.com/articles/figure/_p_Multi-start_FAMoS_searches_solve_the_Blasi_et_al_2016_model_selection_problem_p_/34036816 CC BY 4.0