2026-10-11T21:27:09Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34036777
2026-09-30T20:04:45Z
category_1
category_4
category_146
category_7
category_12
category_14
category_21
category_873
category_734
category_69
portal_63
item_type_6
month_year_09_2026
Dual-Modal
Sensing of Enantiomeric Purity Using Chiral
Au@Cu<sub>x</sub>S Nanoparticles
Hengwei Wang (662379)
Si Li (375535)
Shuhan He (275821)
Shiyu Liu (1265610)
Hengwei Lin (1504414)
Yan Cao (482880)
Biophysics
Biochemistry
Space Science
Medicine
Cell Biology
Molecular Biology
Biotechnology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Inorganic Chemistry
versatile analytical platform
precise molecular recognition
concomitant temperature increase
determining enantiomeric purity
accurate chiral discrimination
gsh ), tryptophan
np surfaces serve
modal sensing platform
italic >< sub
target chiral analytes
nanoparticles enantiomeric discrimination
modal sensing
sub ><
enantiomeric ratios
enantiomeric matrices
chiral plasmonic
chiral au
cys ),
asp ),
></ sub
x </
semiconductor heterostructures
semiconducting properties
rational design
photothermal performances
photothermal conversion
interfacial modulators
highly sensitive
enantioselective interactions
chromogenic substrates
catalytic degradation
biochemical applications
au core
antioxidant capabilities
Enantiomeric
discrimination is essential for a range
of pharmacological
and biochemical applications. Herein, we present a rational design
of chiral Au@Cu<sub><i>x</i></sub>S nanoparticles (NPs)
that serve as a dual-modal sensing platform for determining enantiomeric
purity. By synergizing the localized surface plasmon resonance (LSPR)
of the Au core with the semiconducting properties of the Cu<sub><i>x</i></sub>S shell, these NPs exhibit robust chiroptical activity
alongside enhanced near-infrared (NIR)-responsive photocatalytic and
photothermal performances. We demonstrate that enantioselective interactions
between target chiral analytes with antioxidant capabilities, such
as glutathione (GSH), tryptophan (Trp), aspartic acid (Asp), and cysteine
(Cys), and the NP surfaces serve as mechanisms to modulate reactive
oxygen species (ROS) generation and photothermal conversion. Specifically,
the catalytic degradation of chromogenic substrates and the concomitant
temperature increase are highly sensitive to the enantiomeric ratios
of these analytes, which act as interfacial modulators. This dual-signal
strategy enables rapid and accurate chiral discrimination in enantiomeric
matrices, providing a versatile analytical platform and highlighting
the potential of chiral plasmonic-semiconductor heterostructures in
precise molecular recognition.
2026-09-30T00:00:00Z
Text
Journal contribution
10.1021/acs.inorgchem.6c03832.s001
https://figshare.com/articles/journal_contribution/Dual-Modal_Sensing_of_Enantiomeric_Purity_Using_Chiral_Au_Cu_sub_x_sub_S_Nanoparticles/34036777
CC BY-NC 4.0