2026-10-08T11:19:51Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34036762 2026-09-30T20:20:03Z category_13 category_14 category_21 category_24 category_734 category_931 category_64 category_69 portal_5 item_type_1 month_year_09_2026

<p>Model selection workflow with PEtab Select.</p> Dilan Pathirana (6292544) Frank T. Bergmann (10036117) Domagoj Doresic (25146007) Polina Lakrisenko (10036138) Sebastian Persson (9241307) Niklas Neubrand (25146010) Jens Timmer (25170) Clemens Kreutz (315828) Harald Binder (39439) Marija Cvijovic (4070044) Daniel Weindl (1844341) Jan Hasenauer (328495) Genetics Molecular Biology Biotechnology Evolutionary Biology Biological Sciences not elsewhere classified Information Systems not elsewhere classified Cancer Inorganic Chemistry yield different models parameter estimation problems often competing hypotheses including basic brute g ., akaike existing computational pipelines bayesian information criteria associated calibration problems fair research software model selection tasks model selection problems flexible selection methods petab select introduces petab select builds petab select addresses model selection petab select backward selection sampling methods model alternatives supporting software software package petab standard xlink "> systems biology swift evaluation standard facilitates promoting interoperability one example mathematical modeling first standardization essential contribution ensure flexibility easily extended critical gap compact representation central question broad spectrum biological systems art modelling also advanced <p>(1) The user defines the model selection <b>problem</b>, including the model space and the mathematical description of the set of possible process components, in the <b>standard</b>. (2) The user runs model selection via a <b>calibration tool</b> by sending the PEtab Select problem to the PEtab Select <b>package</b>, which initiates iterations of model selection. (2a) The package provides model candidates to the calibration tool based on the problem specification and the available calibration results. (2b) The calibration tool calibrates the proposed candidate models and sends the calibration results to the package. Iterations of (2a) and (2b) continue until the package sends a termination signal to indicate the end of model selection. The results are provided in the PEtab Select model format and include all calibrated models with their calibration results. (3) The package can be used to perform subsequent analyses and visualizations of the results.</p> 2026-09-30T18:02:09Z Image Figure 10.1371/journal.pcbi.1014774.g001 https://figshare.com/articles/figure/_p_Model_selection_workflow_with_PEtab_Select_p_/34036762 CC BY 4.0