2026-10-12T17:24:44Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34036229 2026-09-30T17:47:06Z category_146 category_7 category_15 category_734 portal_5 item_type_1 month_year_09_2026

<p>Results of the illustrative simulation study.</p> Sahar Khosravi (25145471) Nikolas A. Francis (21575429) Patrick O. Kanold (3190650) Behtash Babadi (5156105) Space Science Medicine Neuroscience Biological Sciences not elsewhere classified offering new insights neuronal populations interact mouse auditory cortex large neuronal ensembles eliciting distinct behaviors active tone discrimination slow temporal dynamics neuronal ensemble activity endogenous neural processes transform sensory information intersection information framework study neural encoding functional connectivity associated div >< p inform behavioral readout also identify neurons photon imaging data behavioral functional taxonomy photon imaging functional connectivity behavioral readout temporal predictability spiking activity point processes functional sensori behavioral relevance sensory stimuli readout properties statistical framework proposed framework vivo </ unified conceptual space modeling proposed methodology passive listening operational modeling noisy observations latent interplay granger ’ granger sensori fundamental challenge external stimuli experimental data existing techniques existing studies driven methodology diverse stimuli <p><b>A)</b> Example of a simulated 10-neuron network. The time courses of the primary and secondary stimuli, as well as the behavioral readout window are shown as inset plots. The receptive fields of neurons 1, 7, and 10, which are influenced by the stimuli, are shown as 2-by-2 matrices. <b>B)</b> Sample simulated trials with the primary stimulus on (left) and off (right). Rows (top to bottom) show the latent AR process (red), spiking activity (black), and resulting two-photon calcium traces (black). The shaded area show the primary stimulus interval. Red circles overlaid on the calcium traces in the bottom panel indicate spikes from the middle panel. <b>C)</b> The ground truth Granger sensori-behavioral functional taxonomy of the network in panel <b>A. D)</b> Sample trial showing estimated and ground-truth signals for a sample neuron (left). Rows top to bottom show estimated vs. true latent AR process, spiking activity, and calcium observations, respectively.</p> 2026-09-30T17:47:02Z Image Figure 10.1371/journal.pcbi.1014820.g002 https://figshare.com/articles/figure/_p_Results_of_the_illustrative_simulation_study_p_/34036229 CC BY 4.0