2026-10-09T06:07:31Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34036226 2026-09-30T17:47:05Z category_146 category_7 category_15 category_734 portal_5 item_type_1 month_year_09_2026

<p>Schematic depiction of the generative model and proposed Granger sensori-behavioral functional taxonomy.</p> Sahar Khosravi (25145471) Nikolas A. Francis (21575429) Patrick O. Kanold (3190650) Behtash Babadi (5156105) Space Science Medicine Neuroscience Biological Sciences not elsewhere classified offering new insights neuronal populations interact mouse auditory cortex large neuronal ensembles eliciting distinct behaviors active tone discrimination slow temporal dynamics neuronal ensemble activity endogenous neural processes transform sensory information intersection information framework study neural encoding functional connectivity associated div >< p inform behavioral readout also identify neurons photon imaging data behavioral functional taxonomy photon imaging functional connectivity behavioral readout temporal predictability spiking activity point processes functional sensori behavioral relevance sensory stimuli readout properties statistical framework proposed framework vivo </ unified conceptual space modeling proposed methodology passive listening operational modeling noisy observations latent interplay granger ’ granger sensori fundamental challenge external stimuli experimental data existing techniques existing studies driven methodology diverse stimuli <p>Top: In the proposed model for estimating GC links directly from two-photon calcium fluorescence observations, observed variables (black), latent endogenous processes (red), and an exogenous stimulus (blue) relevant to the <i>i</i>th and <i>j</i>th neurons are shown. The spiking activity of networked neurons is influenced by latent endogenous processes (red traces) and an exogenous stimulus (blue traces), with black arrows indicating GC connectivity between neurons. The blue and green arrows, respectively, show the effects of the stimulus on neurons and neurons on behavior, in the sense of Granger’s temporal predictability. Bottom: our proposed inverse solution and G-taxonomy; following network parameter estimation, statistical testing, and false discovery rate control, we define three categories of neurons, namely Granger Stimulus, Granger Intersection, and Granger Behavior.</p> 2026-09-30T17:47:02Z Image Figure 10.1371/journal.pcbi.1014820.g001 https://figshare.com/articles/figure/_p_Schematic_depiction_of_the_generative_model_and_proposed_Granger_sensori-behavioral_functional_taxonomy_p_/34036226 CC BY 4.0