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oai:figshare.com:article/34036022 2026-09-30T17:42:57Z category_7 category_12 category_15 category_16 category_873 category_106 category_734 portal_5 item_type_1 month_year_09_2026

The integrated synthesis model. Duncan J. MacGregor (25145402) Medicine Cell Biology Neuroscience Physiology Chemical Sciences not elsewhere classified Science Policy Biological Sciences not elsewhere classified regulate water loss dynamically heterogeneous patterns complete neural system neuronal cell bodies prolonged osmotic challenge peptide hormone vasopressin hypothalamic vasopressin neurons extracellular fluid osmolarity distributed neuroendocrine system stores gradually decline distant hormone stores detailed neuronal model despite upregulated synthesis turn trigger secretion regulate plasma volume maintain hormone supply div >< p 2 +</ sup modelling vasopressin synthesis synthesis dynamics based activity dependent upregulation plasma volume dependent upregulation sustained challenge storage dynamics recovery based neuroendocrine cells model suggests elevated osmolarity neuronal activity large stores coordinate synthesis timescale memory slow recovery several days salt loading posterior pituitary pituitary terminals physiological input mrna content mrna acts intracellular ca homeostatic systems generate complex form part experimentally tested demand balance coupling spiking axonal terminals The spiking model, stimulated by synaptic input that encodes osmotic pressure, drives the synthesis model through its Ca2+ variable C. This regulates the transcription rate T which increases the store of vasopressin mRNA m. The synthesis rate s is proportional to m using a fixed translation rate, and also depletes m. The ghosted link showing activity-dependent regulation of translation was not used in the results here. The synthesis model is coupled to the secretion model through the charging of its reserve store r. 2026-09-30T17:55:49Z Image Figure 10.1371/journal.pcbi.1014832.g009 https://figshare.com/articles/figure/_p_The_integrated_synthesis_model_p_/34036022 CC BY 4.0