2026-10-13T22:18:01Z
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oai:figshare.com:article/34036019
2026-09-30T17:42:56Z
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<p>Refinement of the secretion model.</p>
Duncan J. MacGregor (25145402)
Medicine
Cell Biology
Neuroscience
Physiology
Chemical Sciences not elsewhere classified
Science Policy
Biological Sciences not elsewhere classified
regulate water loss
dynamically heterogeneous patterns
complete neural system
neuronal cell bodies
prolonged osmotic challenge
peptide hormone vasopressin
hypothalamic vasopressin neurons
extracellular fluid osmolarity
distributed neuroendocrine system
stores gradually decline
distant hormone stores
detailed neuronal model
despite upregulated synthesis
turn trigger secretion
regulate plasma volume
maintain hormone supply
div >< p
2 +</ sup
modelling vasopressin synthesis
synthesis dynamics based
activity dependent upregulation
plasma volume
dependent upregulation
sustained challenge
storage dynamics
recovery based
neuroendocrine cells
model suggests
elevated osmolarity
neuronal activity
large stores
coordinate synthesis
timescale memory
slow recovery
several days
salt loading
posterior pituitary
pituitary terminals
physiological input
mrna content
mrna acts
intracellular ca
homeostatic systems
generate complex
form part
experimentally tested
demand balance
coupling spiking
axonal terminals
<p>The quantitative fit of the published secretion model [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.ref003" target="_blank">3</a>] was improved using more detailed <i>in vitro</i> data and better parameter tuning methods based on recent work applying the model to oxytocin neurons [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.ref026" target="_blank">26</a>]. The model is fitted to data measuring both frequency facilitation (top panel) and fatigue (lower panel), simulating the in vitro experimental protocols. The changed parameters are given in the table. The major adjustment was to reduce α which scales the rate of secretion to units of pg.</p>
2026-09-30T17:55:49Z
Image
Figure
10.1371/journal.pcbi.1014832.g008
https://figshare.com/articles/figure/_p_Refinement_of_the_secretion_model_p_/34036019
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