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oai:figshare.com:article/34036013 2026-09-30T17:42:55Z category_7 category_12 category_15 category_16 category_873 category_106 category_734 portal_5 item_type_1 month_year_09_2026

<p>Improving synthesis performance by enhancing transcription or translation.</p> Duncan J. MacGregor (25145402) Medicine Cell Biology Neuroscience Physiology Chemical Sciences not elsewhere classified Science Policy Biological Sciences not elsewhere classified regulate water loss dynamically heterogeneous patterns complete neural system neuronal cell bodies prolonged osmotic challenge peptide hormone vasopressin hypothalamic vasopressin neurons extracellular fluid osmolarity distributed neuroendocrine system stores gradually decline distant hormone stores detailed neuronal model despite upregulated synthesis turn trigger secretion regulate plasma volume maintain hormone supply div >< p 2 +</ sup modelling vasopressin synthesis synthesis dynamics based activity dependent upregulation plasma volume dependent upregulation sustained challenge storage dynamics recovery based neuroendocrine cells model suggests elevated osmolarity neuronal activity large stores coordinate synthesis timescale memory slow recovery several days salt loading posterior pituitary pituitary terminals physiological input mrna content mrna acts intracellular ca homeostatic systems generate complex form part experimentally tested demand balance coupling spiking axonal terminals <p>Two enhancements are compared to the basic (black) experimental data fitted model (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.g005" target="_blank">Figs 5</a> and <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.g006" target="_blank">6</a>), attempting to predict what limits the synthesis response <i>in vivo</i>. Accelerating transcription (red) produces a much faster upregulation of mRNA content and synthesis rate, reducing store depletion but depending on a larger mRNA capacity. Increasing the proportional translation rate (blue) similarly produces a faster upregulation of synthesis, with a more rapid depletion of mRNA content resulting in a lower equilibrium level. This reduces store depletion but likely depends on a translation rate which is beyond the capability of the cells.</p> 2026-09-30T17:55:49Z Image Figure 10.1371/journal.pcbi.1014832.g007 https://figshare.com/articles/figure/_p_Improving_synthesis_performance_by_enhancing_transcription_or_translation_p_/34036013 CC BY 4.0