2026-10-10T05:22:33Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34036010 2026-09-30T17:42:54Z category_7 category_12 category_15 category_16 category_873 category_106 category_734 portal_5 item_type_1 month_year_09_2026

<p>Model challenge and recovery compared to experimental data.</p> Duncan J. MacGregor (25145402) Medicine Cell Biology Neuroscience Physiology Chemical Sciences not elsewhere classified Science Policy Biological Sciences not elsewhere classified regulate water loss dynamically heterogeneous patterns complete neural system neuronal cell bodies prolonged osmotic challenge peptide hormone vasopressin hypothalamic vasopressin neurons extracellular fluid osmolarity distributed neuroendocrine system stores gradually decline distant hormone stores detailed neuronal model despite upregulated synthesis turn trigger secretion regulate plasma volume maintain hormone supply div >< p 2 +</ sup modelling vasopressin synthesis synthesis dynamics based activity dependent upregulation plasma volume dependent upregulation sustained challenge storage dynamics recovery based neuroendocrine cells model suggests elevated osmolarity neuronal activity large stores coordinate synthesis timescale memory slow recovery several days salt loading posterior pituitary pituitary terminals physiological input mrna content mrna acts intracellular ca homeostatic systems generate complex form part experimentally tested demand balance coupling spiking axonal terminals <p>The 100 neuron heterogeneous population here simulates 2 days of basal activity, followed by 5 days of dehydration, and 15 days of recovery, compared against experimental data from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.g001" target="_blank">Fig 1</a>. Two input signal protocols are compared, a default linear ramp (black) and a non-linear ramp (red) with a more rapid initial increase in osmotic signal. Within the variability of the experimental data both ramps are potentially consistent. The linear ramp varies from the store data in its slower initial decline in content, more closely matched by the non-linear ramp, which produces a faster increase in secretion than synthesis, resulting in more rapid initial store depletion. However, in the plasma signal this results in a drop off in response, as the more active neurons become fully depleted. The model was further tested with an added delay between synthesis and store fill rate (blue), simulating the estimated 24h transport delay. The delay only moderately changes the population store depletion and recovery profile, but also results in an earlier drop off in the plasma signal due to store depletion.</p> 2026-09-30T17:55:49Z Image Figure 10.1371/journal.pcbi.1014832.g006 https://figshare.com/articles/figure/_p_Model_challenge_and_recovery_compared_to_experimental_data_p_/34036010 CC BY 4.0