2026-10-13T05:29:38Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34036004 2026-09-30T17:42:53Z category_7 category_12 category_15 category_16 category_873 category_106 category_734 portal_5 item_type_1 month_year_09_2026

<p>Basal activity and prolonged challenge and recovery in a heterogeneous population.</p> Duncan J. MacGregor (25145402) Medicine Cell Biology Neuroscience Physiology Chemical Sciences not elsewhere classified Science Policy Biological Sciences not elsewhere classified regulate water loss dynamically heterogeneous patterns complete neural system neuronal cell bodies prolonged osmotic challenge peptide hormone vasopressin hypothalamic vasopressin neurons extracellular fluid osmolarity distributed neuroendocrine system stores gradually decline distant hormone stores detailed neuronal model despite upregulated synthesis turn trigger secretion regulate plasma volume maintain hormone supply div >< p 2 +</ sup modelling vasopressin synthesis synthesis dynamics based activity dependent upregulation plasma volume dependent upregulation sustained challenge storage dynamics recovery based neuroendocrine cells model suggests elevated osmolarity neuronal activity large stores coordinate synthesis timescale memory slow recovery several days salt loading posterior pituitary pituitary terminals physiological input mrna content mrna acts intracellular ca homeostatic systems generate complex form part experimentally tested demand balance coupling spiking axonal terminals <p>The data here show a 100 neuron heterogeneous population following the same protocols as <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.g004" target="_blank">Fig 4</a>. The inset distribution shows the heterogeneous input rates and the colour coded example neurons. In the left hand plots, with default synthesis scaling <i>s</i>_<i>r</i> = 1.1, the heterogeneous population sustains a stable reserve store at basal activity (1 pg/ml plasma vasopressin). The majority of the secretion is from the more active neurons (red) and these show gradual increase of individual neuron stores. In the right hand plots, the challenge and recovery protocol shows similar results to the single neuron (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014832#pcbi.1014832.g004" target="_blank">Fig 4</a>), but with a more stable and linear plasma signal. The individual neurons show some complex divergence in their store recovery, due to varied non-linearities in secretion and synthesis. The more active cells, even with highly elevated mRNA, show more rapid depletion, but also a more rapid, and even excess recovery.</p> 2026-09-30T17:55:49Z Image Figure 10.1371/journal.pcbi.1014832.g005 https://figshare.com/articles/figure/_p_Basal_activity_and_prolonged_challenge_and_recovery_in_a_heterogeneous_population_p_/34036004 CC BY 4.0