2026-10-14T13:12:52Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34035998 2026-09-30T17:42:51Z category_7 category_12 category_15 category_16 category_873 category_106 category_734 portal_5 item_type_1 month_year_09_2026

<p>Single neuron transcription-dependent regulation of mRNA content and synthesis rates.</p> Duncan J. MacGregor (25145402) Medicine Cell Biology Neuroscience Physiology Chemical Sciences not elsewhere classified Science Policy Biological Sciences not elsewhere classified regulate water loss dynamically heterogeneous patterns complete neural system neuronal cell bodies prolonged osmotic challenge peptide hormone vasopressin hypothalamic vasopressin neurons extracellular fluid osmolarity distributed neuroendocrine system stores gradually decline distant hormone stores detailed neuronal model despite upregulated synthesis turn trigger secretion regulate plasma volume maintain hormone supply div >< p 2 +</ sup modelling vasopressin synthesis synthesis dynamics based activity dependent upregulation plasma volume dependent upregulation sustained challenge storage dynamics recovery based neuroendocrine cells model suggests elevated osmolarity neuronal activity large stores coordinate synthesis timescale memory slow recovery several days salt loading posterior pituitary pituitary terminals physiological input mrna content mrna acts intracellular ca homeostatic systems generate complex form part experimentally tested demand balance coupling spiking axonal terminals <p>For illustration, rather than physiological simulation, the model here is initialised with a full store and zero stimulus, switching at time 0 to a sustained highly osmotic input signal. Transcription drives the accumulation of mRNA content, which in turn determines the rate of synthesis which maintains (or slows the depletion of) hormone stores. In the rapid change to a highly stimulated state here, elevated synthesis is not sufficient to match the rate of secretion, and stores are gradually depleted. When the stores are depleted the rate of secretion becomes purely synthesis rate dependent.</p> 2026-09-30T17:55:49Z Image Figure 10.1371/journal.pcbi.1014832.g003 https://figshare.com/articles/figure/_p_Single_neuron_transcription-dependent_regulation_of_mRNA_content_and_synthesis_rates_p_/34035998 CC BY 4.0