2026-10-12T18:36:16Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34035995 2026-09-30T17:42:50Z category_7 category_12 category_15 category_16 category_873 category_106 category_734 portal_5 item_type_1 month_year_09_2026

<p>Spike activity dependent regulation of transcription.</p> Duncan J. MacGregor (25145402) Medicine Cell Biology Neuroscience Physiology Chemical Sciences not elsewhere classified Science Policy Biological Sciences not elsewhere classified regulate water loss dynamically heterogeneous patterns complete neural system neuronal cell bodies prolonged osmotic challenge peptide hormone vasopressin hypothalamic vasopressin neurons extracellular fluid osmolarity distributed neuroendocrine system stores gradually decline distant hormone stores detailed neuronal model despite upregulated synthesis turn trigger secretion regulate plasma volume maintain hormone supply div >< p 2 +</ sup modelling vasopressin synthesis synthesis dynamics based activity dependent upregulation plasma volume dependent upregulation sustained challenge storage dynamics recovery based neuroendocrine cells model suggests elevated osmolarity neuronal activity large stores coordinate synthesis timescale memory slow recovery several days salt loading posterior pituitary pituitary terminals physiological input mrna content mrna acts intracellular ca homeostatic systems generate complex form part experimentally tested demand balance coupling spiking axonal terminals <p>Phasic spiking in a highly stimulated integrate-and-fire based model neuron is both driven by and generates Ca²⁺ entry, producing an intracellular Ca²⁺ signal that is used to drive the model’s vasopressin mRNA transcription rate. The essential dynamic is that the mechanism translates the rapidly changing and noisy electrical activity into a sustained slow-changing measure of activity.</p> 2026-09-30T17:55:49Z Image Figure 10.1371/journal.pcbi.1014832.g002 https://figshare.com/articles/figure/_p_Spike_activity_dependent_regulation_of_transcription_p_/34035995 CC BY 4.0