2026-10-14T02:58:58Z
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oai:figshare.com:article/34035971
2026-09-30T17:42:41Z
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<p>Proportions of direct and indirect effects.</p>
Sophie Breunig (25145387)
Kristen M. Kelly (9340507)
Lukas S. Schaffer (25145390)
Jeremy M. Lawrence (25145393)
Younga Heather Lee (25145396)
Elizabeth W. Karlson (11935646)
Andrew D. Grotzinger (6252026)
Genetics
Molecular Biology
Immunology
Biological Sciences not elsewhere classified
Science Policy
Mental Health
literature extensively describes
latent genomic factors
highly attenuated associations
g ., c
g ., autoimmune
crohn &# 8217
multiple disorder clusters
examined immune markers
14 immune markers
crp ], interleukin
13 psychiatric disorders
immune disease link
6 mediated 60
multiple markers
immune markers
psychiatric disorders
genetic link
many immune
immune diseases
11 immune
xlink ">
study explored
significant mediators
results indicated
reactive protein
psychiatric traits
psychiatric relevance
psychiatric relationships
overlapping signal
mediated diseases
limited understanding
investigated whether
internalizing factor
genetic links
genetic liability
diagnostic relevance
biological precursor
better explained
<p>Pie charts are displaying the proportions of the direct and indirect effects for each of the mediation models tested. The size of the pie charts represents the size of the total effect. Immune, autoimmune diseases; Mixed, mixed immune pattern diseases; Int, internalizing disorders; SUD, substance use disorders; CD, Crohn’s disease; ADHD, attention-deficit/hyperactivity disorder. <b>A</b> displays all factor-factor relationships and <b>B</b> displays all factor-trait relationships.</p>
2026-09-30T17:56:49Z
Image
Figure
10.1371/journal.pgen.1012328.g005
https://figshare.com/articles/figure/_p_Proportions_of_direct_and_indirect_effects_p_/34035971
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