2026-10-13T05:28:28Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34035573
2026-09-30T17:35:05Z
category_4
category_12
category_13
category_14
category_734
portal_5
item_type_1
month_year_09_2026
<p>Location of residues mutated in orc4-R267A-suppressor alleles in 3D protein structures.</p>
Luis E. MartÃnez-RodrÃguez (25145346)
Stephen P. Bell (25145349)
Biochemistry
Cell Biology
Genetics
Molecular Biology
Biological Sciences not elsewhere classified
origin recognition complex
saccharomyces cerevisiae </
helicase loading activity
div >< p
atpase interfaces within
six orc subunits
orc atp hydrolysis
defective orc allele
atp hydrolysis
orc subunits
defective orc
vitro </
toa2 </
r267a </
sixth allele
reducing transcription
orc4r ).
lethal phenotype
genetic screen
essential role
cdc6 complex
binds origins
although functions
<p>A) The ORC-Cdc6 complex bound to DNA (PDB: 7MCA). The location of each ORC <i>sofa</i> allele is marked in the full structure by a black box, and an enlarged version of the same region is shown. The mutated residue and respective subunits are indicated. ATP, DNA, other protein subunits or AAA+ motif residues visible in the enlarged region are also labeled. B) The TFIIA-TBP-DNA complex bound to DNA (PDB: 1NH2). In the structure, the mutated Toa2 residue (G16) is shown as red spheres. An enlarged version of the region including the mutated residue is shown. Hydrophobic residues on both Toa1 and Toa2 near the mutated residue are shown as grey spheres in the enlargement.</p>
2026-09-30T17:34:54Z
Image
Figure
10.1371/journal.pone.0349465.g002
https://figshare.com/articles/figure/_p_Location_of_residues_mutated_in_orc4-R267A-suppressor_alleles_in_3D_protein_structures_p_/34035573
CC BY 4.0