2026-10-14T01:01:20Z
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2026-09-30T17:35:00Z
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<p>Suppression of the <i>orc4-R267A</i> lethal phenotype by general transcription factor alleles at 30.</p>
Luis E. MartÃnez-RodrÃguez (25145346)
Stephen P. Bell (25145349)
Biochemistry
Cell Biology
Genetics
Molecular Biology
Biological Sciences not elsewhere classified
origin recognition complex
saccharomyces cerevisiae </
helicase loading activity
div >< p
atpase interfaces within
six orc subunits
orc atp hydrolysis
defective orc allele
atp hydrolysis
orc subunits
defective orc
vitro </
toa2 </
r267a </
sixth allele
reducing transcription
orc4r ).
lethal phenotype
genetic screen
essential role
cdc6 complex
binds origins
although functions
<p>Ten-fold serial dilutions of <i>ORC4</i> or <i>orc4-R267A</i> plasmid-shuffle strains with additional point mutation in the indicated gene involved in RNA Pol II transcription. Strains were incubated for 4 days at 30. Strains are the same as <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0349465#pone.0349465.g006" target="_blank">Fig 6</a>.</p> <p>(TIF)</p>
2026-09-30T17:34:54Z
Image
Figure
10.1371/journal.pone.0349465.s006
https://figshare.com/articles/figure/_p_Suppression_of_the_i_orc4-R267A_i_lethal_phenotype_by_general_transcription_factor_alleles_at_30_p_/34035558
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