2026-10-14T21:33:33Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34035274
2026-09-30T17:32:51Z
category_12
category_21
category_46
category_811
category_64
category_106
category_132
portal_5
item_type_3
month_year_09_2026
<p>Dataset.</p>
Tomonari Shimagaki (10177670)
Atsushi Maeda (436456)
Tomoya Harima (25145290)
Akihiro Sakai (81092)
Rumi Matono (25145293)
Naotaka Hashimoto (25145296)
Shohei Yamaguchi (3833263)
Kozo Konishi (25145299)
Kenkichi Hashimoto (25145302)
Takashi Maeda (145189)
Cell Biology
Biotechnology
Immunology
Mathematical Sciences not elsewhere classified
Cancer
Science Policy
Infectious Diseases
severe postoperative complications
readily available biomarkers
multivariate analysis identified
integrate host inflammatory
40 &# 8211
37 &# 8211
significantly poorer dfs
low cally index
cally index groups
lower albumin levels
crp )- albumin
high cally index
significantly worse dfs
low (< 2
preoperative cally index
high (≥ 2
underwent hepatic resection
hr ), 1
ci ), 1
cally index
dfs ),
worse dfs
underwent resection
high risk
higher crp
fetoprotein levels
hepatic resection
preoperative c
xlink ">
score matching
remains frequent
reactive protein
prognostic significance
prognostic factors
overall survival
lymphocyte index
larger tumors
independently associated
hepatocellular carcinoma
hazard ratio
free survival
confidence interval
<div>
<p>Background</p><p>Postoperative recurrence after hepatic resection for hepatocellular carcinoma (HCC) remains frequent. Readily available biomarkers that integrate host inflammatory, immune, and nutritional statuses may improve risk stratification. In this study, we evaluated the prognostic significance of the preoperative C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index in patients who underwent resection for primary HCC.</p>
<p>Methods</p><p>This retrospective, single-center study included 611 patients who underwent hepatic resection for primary HCC between 2004 and 2022. The CALLY index was defined as (albumin × lymphocytes)/(CRP × 10<sup>4</sup>). Patients were classified into high (≥ 2.2) and low (< 2.2) CALLY index groups. Clinicopathological factors, disease-free survival (DFS), and overall survival (OS) were compared. Prognostic factors were assessed using Cox proportional hazards models, and propensity-score matching was performed.</p>
<p>Results</p><p>The low CALLY index group had lower albumin levels, higher CRP and alpha-fetoprotein levels, larger tumors, and more severe postoperative complications than the high CALLY index group. Patients with low CALLY index had significantly worse DFS and OS than those with high CALLY index. Multivariate analysis identified that the low CALLY index was independently associated with worse DFS (hazard ratio (HR), 1.86; 95% confidence interval (CI), 1.40–2.47; P < 0.0001) and OS (HR, 1.93; 95% CI, 1.37–2.72; P = 0.0002). After propensity-score matching, the low CALLY index group continued to have significantly poorer DFS and OS rates than the high CALLY index group.</p>
<p>Conclusions</p><p>The preoperative CALLY index was independently associated with DFS and OS after hepatic resection for primary HCC. This simple biomarker may help identify patients at a high risk of recurrence and poor survival.</p></div>
2026-09-30T17:32:45Z
Dataset
Dataset
10.1371/journal.pone.0358776.s005
https://figshare.com/articles/dataset/_p_Dataset_p_/34035274
CC BY 4.0