2026-10-10T12:01:43Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34035127 2026-09-30T17:31:15Z category_21 category_272 category_734 category_64 category_106 category_132 category_134 portal_5 item_type_6 month_year_09_2026

<p>Checklist.</p> Neha Janrode (25145218) Yohhei Hamada (12334192) Arshad Taliep (20900855) Lauren Barron (24419908) Walter Chabaya (24476453) Rene T. Goliath (25145221) Trinh Duong (311438) Amanda Jackson (59852) Shireen Galant (20900852) Nashreen Omar-Davies (3193035) Louise Lai Sai (11196696) Lillian Twentiey (24476454) Robert J. Wilkinson (7724204) Molebogeng X. Rangaka (9258426) Biotechnology Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Cancer Science Policy Infectious Diseases Virology single sputum specimen consecutively enrolled adults 6 %), compared 8 &# 8211 2 &# 8211 ray abnormalities suggestive enrolled 673 participants 1 &# 8211 based tb screening although chest x 60 years ), tuberculosis screening tools slightly reduced specificity 6 %, 95 diabetes </ p 2 %, 95 screening tools 54 years chest x 6 %). xpert ultra weight loss tb demonstrated south africa significantly lower remained suboptimal reference standard reduced specificity prior tb prevalent tb night sweats median age hiv prevalence confidence interval 33 %). 3 %) 01 ). <div><p>Systematic screening for tuberculosis (TB) is recommended in people with diabetes; however, data on the accuracy of screening tools in this population are lacking. We assessed the accuracy of symptom and chest X-ray screening among people with diabetes. We consecutively enrolled adults with diabetes attending routine care in South Africa. All participants underwent symptom screening and chest X-ray. A single sputum specimen was collected from all participants and tested by Xpert Ultra. A positive Xpert Ultra result was used as the reference standard. We enrolled 673 participants. The median age was 54 years (interquartile range 47–60 years), and 63.8% were female. HIV prevalence was 17.2%. Prevalent TB was diagnosed in nine participants (1.33%). Any cough had a sensitivity of 22.2% (95% confidence interval [CI] 2.1-60.0%) and a specificity of 97.5% (95%CI 96.0-98.6%). Expanding the symptom definition to include any of cough, fever, weight loss, or night sweats did not improve sensitivity (22.2%, 95% CI 2.1–60.0) and slightly reduced specificity to 96.0% (95% CI 94.2–97.0). Chest X-ray abnormalities suggestive of TB demonstrated a sensitivity of 55.6% (95%CI 21.2-86.3%) and a specificity of 95.4% (95%CI 93.4-97.0%). The specificity of chest X-ray was significantly lower in participants with prior TB (87.6%, 95% CI: 79.8–90.6%), compared to 97.2% (95% CI: 95.2–98.5%) in those without (p < 0.01). Symptom-based TB screening has poor sensitivity in people with diabetes. Although chest X-ray improved the sensitivity, it remained suboptimal, with a reduced specificity in people with previous TB.</p></div> 2026-09-30T17:31:05Z Text Journal contribution 10.1371/journal.pgph.0006479.s007 https://figshare.com/articles/journal_contribution/_p_Checklist_p_/34035127 CC BY 4.0