2026-10-13T19:30:57Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34034943
2026-09-30T17:29:09Z
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<p>PRISMA-P checklist.</p>
Sahar Khademioore (17319385)
João Pedro Lima (22857591)
Dena Zeraatkar (3939671)
Sadia Mahmood (14799594)
Sara Khademioureh (10318843)
Charles C. Wykoff (8550325)
Peter K. Kaiser (6876878)
Tien-Yin Wong (159436)
Jiayuan Cheng (24091461)
Mengda Li (25145166)
Varun Chaudhary (37352)
Medicine
Cell Biology
Biotechnology
Cancer
Infectious Diseases
Computational Biology
vitreoretinal condition affecting
thickness macular hole
synthesized using random
surgical techniques may
synthesize current evidence
xlink "> full
ftmh surgical outcomes
xlink ">
surgical decision
assessed using
visual acuity
systematically evaluate
systematic review
search pubmed
science databases
recommendations assessment
predictive value
ophthoevidence report
minimum follow
foveal center
cochrane library
clinical utility
achieving closure
<div>
<p>Background</p><p>Full-thickness macular hole (FTMH) is a vitreoretinal condition affecting the foveal center that causes central vision loss and metamorphopsia. Despite high surgical success in achieving closure, functional visual recovery remains unpredictable. Identifying reliable optical coherence tomography (OCT) biomarkers that predict postoperative outcomes could improve patient counselling and surgical decision-making.</p>
<p>Objective</p><p>To systematically evaluate the predictive value of baseline structural OCT biomarkers for visual acuity (VA) outcomes at 3, 6, 12, and 24 months following FTMH surgery.</p>
<p>Methods</p><p>We will search PubMed, EMBASE, Cochrane Library, and Web of Science databases from inception for studies evaluating baseline OCT parameters as predictors of postoperative VA outcomes following FTMH surgery, with minimum follow-up of 3 months. Data will be synthesized using random-effects meta-analyses. The certainty of evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.</p>
<p>Conclusions</p><p>This systematic review will synthesize current evidence on OCT biomarkers’ predictive value for FTMH surgical outcomes. The findings will clarify their clinical utility and may inform individualized prognostic counselling and surgical decision-making, including which patients are most likely to benefit from surgery and which surgical techniques may be most effective given specific OCT profiles.</p></div>
2026-09-30T17:29:07Z
Text
Journal contribution
10.1371/journal.pone.0359108.s001
https://figshare.com/articles/journal_contribution/_p_PRISMA-P_checklist_p_/34034943
CC BY 4.0