2026-10-10T03:10:23Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34034832
2026-09-30T17:28:14Z
category_7
category_21
category_734
category_64
category_132
category_135
portal_5
item_type_6
month_year_09_2026
<p>PRISMA-P-checklist.</p>
Philmon Dejen (20308535)
Belay Beyene (4098613)
Tizazu Zenebe Zelelie (16455663)
Amanuel Kelem (15910221)
Abiel Teshome (25145136)
Mahider Ayalew (25145139)
Techalew Shimelis (3599390)
Medicine
Biotechnology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
Computational Biology
two independent reviewers
remain clinically silent
quality assessment using
inform targeted interventions
including google scholar
comprehensive literature search
african journals online
based malaria surveillance
generate comprehensive evidence
conduct study selection
support malaria control
malaria transmission due
plasmodium species distribution
2 </ sup
actual data collection
analysis </ p
malaria control
species distribution
data collection
asymptomatic malaria
transmission season
synthesize evidence
study design
study area
data extraction
xlink ">
systematic review
subgroup analyses
risk factors
q test
prespecified factors
potential reservoir
partial immunity
p guidelines
major challenge
increasingly recognized
frequent exposure
epidemiological importance
endemic settings
elimination strategies
elimination efforts
eligible studies
electronic databases
diagnostic method
analysis aim
allows infections
aged children
<div>
<p>Background</p><p>Asymptomatic malaria infection remains a major challenge for malaria control and elimination efforts, particularly in endemic settings such as Ethiopia. School-aged children are increasingly recognized as a potential reservoir for malaria transmission due to frequent exposure to infection and the development of partial immunity that allows infections to remain clinically silent. However, available evidence on the burden, species distribution, and determinants of asymptomatic malaria in this population is fragmented and inconsistent. This systematic review and meta-analysis aim to synthesize evidence on the prevalence, Plasmodium species distribution, and risk factors of asymptomatic malaria among school-aged children in Ethiopia.</p>
<p>Methods</p><p>This protocol was developed in accordance with the PRISMA-P guidelines. A comprehensive literature search will be conducted in electronic databases (PubMed, Scopus, CINAHL, and ScienceDirect) and additional sources, including Google Scholar and African Journals Online. Eligible studies will include observational studies reporting asymptomatic malaria among school-aged children in Ethiopia. Two independent reviewers will conduct study selection, data extraction, and quality assessment using the Joanna Briggs Institute critical appraisal tool for prevalence studies. A random-effects meta-analysis will be performed using R software to estimate the pooled prevalence. Heterogeneity will be assessed using Cochran’s Q test and I<sup>2</sup> statistics, and subgroup analyses will be conducted by diagnostic method, study area, study design, years of actual data collection, and transmission season during data collection. Where sufficiently comparable adjusted estimates are available, associations between prespecified factors and AMI will also be quantitatively synthesized.</p>
<p>Conclusion</p><p>The findings will generate comprehensive evidence to support malaria control and elimination strategies in Ethiopia by highlighting the epidemiological importance of school-aged children as a potential reservoir for infection. The results are expected to inform targeted interventions and strengthen school-based malaria surveillance and prevention programs.</p></div>
2026-09-30T17:28:11Z
Text
Journal contribution
10.1371/journal.pone.0359714.s001
https://figshare.com/articles/journal_contribution/_p_PRISMA-P-checklist_p_/34034832
CC BY 4.0