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oai:figshare.com:article/34034770 2026-09-30T17:27:46Z category_8 category_14 category_21 category_46 category_62 category_64 category_106 category_132 category_134 portal_5 item_type_1 month_year_09_2026

<p>Representative preoperative (left) and postoperative (right) slit-lamp photographs illustrating surgical interventions selected according to the severity-based surgical algorithm for refractory Mooren’s ulcer.</p> Minghai Huang (9525231) Zhifeng Wu (303016) Dongmei Wei (3836542) Jixiao Nong (25145089) Zhuoyuan Zhang (6628634) Thuthuy Hoang (25145092) Guina Yin (25145095) Microbiology Molecular Biology Biotechnology Immunology Marine Biology Cancer Science Policy Infectious Diseases Virology underwent surgical intervention mooren &# 8217 meier analysis showed final anatomical success failing medical therapy based surgical strategy based surgical algorithm amniotic membrane transplantation although bcva improved aggressive disease biology ulcers &# 8805 primary healing rates higher recurrence risks corrected visual acuity bcva ), recurrence perforations &# 8804 3 stromal thickness amt group compared recurrence rates ulcers involving median recurrence functional acuity xlink "> term follow technical infeasibility sustained immunomodulation severe cases retrospective series penetrating keratoplasty overall 95 nlp ). mean follow local immunosuppression lamellar keratoplasty january 2024 free survival february 2016 clinical outcomes 84 ). 8 %). 36 months 30 months 24 eyes <p>(A, a) AMT: The transplanted opaque amniotic membrane integrated with the recipient cornea, restoring structural integrity. (B, b) Partial LK: C-shaped LK for deep corneal ulcer presenting as descemetoceles, demonstrating graft transparency and restored corneal structural integrity. (C, c) Double-layer LK for a 4 mm corneal perforation with iris prolapse: A large D-shaped outer lamellar graft overlying a small, thin inner patch graft secured at the nasal perforation site, showing postoperative graft transparency and structural integrity. (D, d) Total LK for extensive peripheral corneal ulceration extending over 9 clock hours with central involvement, showing postoperative interface haze and vascularization while maintaining structural integrity. (E, e) Large C-shaped PK for extensive peripheral corneal ulceration spanning 9 clock hours with a 5 mm paracentral perforation, demonstrating mild postoperative graft edema while preserving corneal structural integrity and the recipient's nasal cornea. Abbreviations: AMT, amniotic membrane transplantation; LK, lamellar keratoplasty; PK, penetrating keratoplasty. Reprinted under a CC BY license, with permission from Nanning Aier Eye Hospital, original copyright 2016–2024.</p> 2026-09-30T17:27:38Z Image Figure 10.1371/journal.pone.0359413.g003 https://figshare.com/articles/figure/_p_Representative_preoperative_left_and_postoperative_right_slit-lamp_photographs_illustrating_surgical_interventions_selected_according_to_the_severity-based_surgical_algorithm_for_refractory_Mooren_s_ulcer_p_/34034770 CC BY 4.0