2026-10-13T12:23:56Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34034761 2026-09-30T17:27:41Z category_8 category_14 category_21 category_46 category_62 category_64 category_106 category_132 category_134 portal_5 item_type_3 month_year_09_2026

<p>Individual Patient-Level Clinical Data of 24 Cases of Refractory Mooren’s Ulcer Treated with Severity-Based Surgical Algorithm.</p> Minghai Huang (9525231) Zhifeng Wu (303016) Dongmei Wei (3836542) Jixiao Nong (25145089) Zhuoyuan Zhang (6628634) Thuthuy Hoang (25145092) Guina Yin (25145095) Microbiology Molecular Biology Biotechnology Immunology Marine Biology Cancer Science Policy Infectious Diseases Virology underwent surgical intervention mooren &# 8217 meier analysis showed final anatomical success failing medical therapy based surgical strategy based surgical algorithm amniotic membrane transplantation although bcva improved aggressive disease biology ulcers &# 8805 primary healing rates higher recurrence risks corrected visual acuity bcva ), recurrence perforations &# 8804 3 stromal thickness amt group compared recurrence rates ulcers involving median recurrence functional acuity xlink "> term follow technical infeasibility sustained immunomodulation severe cases retrospective series penetrating keratoplasty overall 95 nlp ). mean follow local immunosuppression lamellar keratoplasty january 2024 free survival february 2016 clinical outcomes 84 ). 8 %). 36 months 30 months 24 eyes <p>AMT, amniotic membrane transplantation; LK, lamellar keratoplasty; PK, penetrating keratoplasty; BCVA, best-corrected visual acuity (decimal); HM, hand motion; NLP, no light perception; FC, finger counting; CT, corneal thickness; Perf., perforation; OD, right eye; OS, left eye; B/L, bilateral; U/L, unilateral. Note: Of the 24 patients, 8 had bilateral disease. To ensure data independence and avoid inter-eye correlation bias, only the surgically reconstructed eye (AMT, LK, or PK) was analyzed for each patient; contralateral eyes were successfully controlled with conservative management alone. Symptom duration refers to the interval from the onset of ocular symptoms (as reported by the patient) to the date of surgical intervention at our institution. BCVA is presented in decimal notation. For statistical analysis, HM and FC were assigned logMAR values of 2.30 and 2.00, respectively. Em dash (—) in the “Time to First Recurrence” column indicates that no recurrence event occurred during follow-up. “NA” (not applicable) for Case 2 indicates that the eye was excluded from recurrence analysis due to failed initial healing after lamellar keratoplasty.</p> <p>(XLSX)</p> 2026-09-30T17:27:38Z Dataset Dataset 10.1371/journal.pone.0359413.s001 https://figshare.com/articles/dataset/_p_Individual_Patient-Level_Clinical_Data_of_24_Cases_of_Refractory_Mooren_s_Ulcer_Treated_with_Severity-Based_Surgical_Algorithm_p_/34034761 CC BY 4.0