2026-10-12T16:38:06Z
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2026-09-30T17:26:56Z
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<p>Effects of AZP2006 in aged mice infused with α-syn PFF preparation in the SNpc, treated for 5 weeks.</p>
Noelle Callizot (5660677)
Georgia Culley (15148575)
Grace Flower (25145065)
Laura Rouvière (16400955)
Véronique De Conto (25145068)
Alexandre Wojcinski (6340172)
Catherine Botto (25145071)
Cecilia Estrella (1618609)
Alexandre Henriques (359791)
Philippe Verwaerde (1618624)
Biochemistry
Cell Biology
Genetics
Molecular Biology
Neuroscience
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Cancer
promising therapeutic approach
lewy bodies ).
several lysosomal enzymes
restoring lysosomal homeostasis
lysosomal availability depend
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maintaining lysosomal function
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neuroprotective effects involve
several parkinson ’
lysosomal function
neuroprotective effects
lysosomal system
lysosomal dysfunction
parkinson ’
neuroprotective action
disease models
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vitro </
ultimately supporting
prone proteins
pathohistological hallmarks
mitochondrial injury
genetic connections
endoplasmic reticulum
dopaminergic neurons
direct link
clinical development
<p>Body mass evolution during 35 days of daily treatment with vehicle or AZP2006 post-lesion (A). Representative IHC images TH (red)/α-syn (green)/Iba1 (purple) (B). IHC analysis shows the total number of TH(+) neurons (C), area of α-syn accumulation in TH(+) neurons (D) and the number of Iba1(+) microglia in the SNpc (E) expressed as % of sham. Raw values for sham (i.e., 100%); TH(+) neurons = 65 ± 1.6; α-syn area/TH(+) neuron = 168 ± 9.4 µm<sup>2</sup>; Iba1(+) cells = 53 ± 2.8. Each bar represents the mean ± SEM, one-way ANOVA followed by Fisher’s test. <sup>##</sup>p < 0.01 or <sup>####</sup>p < 0.0001 from sham; **p < 0.01; ***p < 0.001 and ****p < 0.0001 from α-syn+vehicle injury, (n = 7 mice / group).</p>
2026-09-30T17:26:42Z
Image
Figure
10.1371/journal.pone.0359269.g005
https://figshare.com/articles/figure/_p_Effects_of_AZP2006_in_aged_mice_infused_with_-syn_PFF_preparation_in_the_SNpc_treated_for_5_weeks_p_/34034689
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