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        <datestamp>2026-09-30T17:26:48Z</datestamp>
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          <dc:title>&lt;p&gt;Effect of neuronal survival following MPP&lt;sup&gt;+&lt;/sup&gt; (500 nM or 1 mM, 48h) to wild-type (WT) or PGRN knock-out (KO) SH-SY5Y cell cultures.&lt;/p&gt;</dc:title>
          <dc:creator>Noelle Callizot (5660677)</dc:creator>
          <dc:creator>Georgia Culley (15148575)</dc:creator>
          <dc:creator>Grace Flower (25145065)</dc:creator>
          <dc:creator>Laura Rouvière (16400955)</dc:creator>
          <dc:creator>Véronique De Conto (25145068)</dc:creator>
          <dc:creator>Alexandre Wojcinski (6340172)</dc:creator>
          <dc:creator>Catherine Botto (25145071)</dc:creator>
          <dc:creator>Cecilia Estrella (1618609)</dc:creator>
          <dc:creator>Alexandre Henriques (359791)</dc:creator>
          <dc:creator>Philippe Verwaerde (1618624)</dc:creator>
          <dc:subject>Biochemistry</dc:subject>
          <dc:subject>Cell Biology</dc:subject>
          <dc:subject>Genetics</dc:subject>
          <dc:subject>Molecular Biology</dc:subject>
          <dc:subject>Neuroscience</dc:subject>
          <dc:subject>Chemical Sciences not elsewhere classified</dc:subject>
          <dc:subject>Biological Sciences not elsewhere classified</dc:subject>
          <dc:subject>Cancer</dc:subject>
          <dc:subject>promising therapeutic approach</dc:subject>
          <dc:subject>lewy bodies ).</dc:subject>
          <dc:subject>several lysosomal enzymes</dc:subject>
          <dc:subject>restoring lysosomal homeostasis</dc:subject>
          <dc:subject>lysosomal availability depend</dc:subject>
          <dc:subject>like models (&lt;</dc:subject>
          <dc:subject>parkinson &amp;# 8217</dc:subject>
          <dc:subject>maintaining lysosomal function</dc:subject>
          <dc:subject>div &gt;&lt; p</dc:subject>
          <dc:subject>neuroprotective effects involve</dc:subject>
          <dc:subject>several parkinson ’</dc:subject>
          <dc:subject>lysosomal function</dc:subject>
          <dc:subject>neuroprotective effects</dc:subject>
          <dc:subject>lysosomal system</dc:subject>
          <dc:subject>lysosomal dysfunction</dc:subject>
          <dc:subject>parkinson ’</dc:subject>
          <dc:subject>neuroprotective action</dc:subject>
          <dc:subject>disease models</dc:subject>
          <dc:subject>vivo &lt;/</dc:subject>
          <dc:subject>vitro &lt;/</dc:subject>
          <dc:subject>ultimately supporting</dc:subject>
          <dc:subject>prone proteins</dc:subject>
          <dc:subject>pathohistological hallmarks</dc:subject>
          <dc:subject>mitochondrial injury</dc:subject>
          <dc:subject>genetic connections</dc:subject>
          <dc:subject>endoplasmic reticulum</dc:subject>
          <dc:subject>dopaminergic neurons</dc:subject>
          <dc:subject>direct link</dc:subject>
          <dc:subject>clinical development</dc:subject>
          <dc:description>&lt;p&gt;ICC analysis of cultures show the total number of TH(+) neurons, expressed as % of control (CTR). Raw values for CTR (i.e., 100%); cells/field WT SH-SY5Y 142 ± 44. Each bar represents the mean ± SEM, two-way ANOVA followed Fisher’s LSD test. ***p &lt; 0.001 and ****p &lt; 0.0001 from CTR (respectively) (n = 4–6 / group).&lt;/p&gt; &lt;p&gt;(TIF)&lt;/p&gt;</dc:description>
          <dc:date>2026-09-30T17:26:42Z</dc:date>
          <dc:type>Image</dc:type>
          <dc:type>Figure</dc:type>
          <dc:identifier>10.1371/journal.pone.0359269.s005</dc:identifier>
          <dc:relation>https://figshare.com/articles/figure/_p_Effect_of_neuronal_survival_following_MPP_sup_sup_500_nM_or_1_mM_48h_to_wild-type_WT_or_PGRN_knock-out_KO_SH-SY5Y_cell_cultures_p_/34034662</dc:relation>
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