2026-10-09T17:56:33Z
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2026-09-30T17:25:18Z
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<p>Comparative changes in cytokines present in the circulation 30 – 270 days after sham-irradiation with HLU compared with sham-irradiation no HLU.</p>
Marek Lenarczyk (11483998)
Amy Kronenberg (4229725)
Andy Kwok (11484016)
Alexander Borg (10656692)
Ammar J. Alsheikh (25145023)
Angela J. Mathison (7335572)
Michael T. Zimmermann (161961)
Samuel B. R. Lawton (25145026)
Hershel Raff (365791)
Jeffrey Willey (10341092)
Richard A. Komorowski (25145029)
Raul Urrutia (1537)
John E. Baker (15360761)
Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Genetics
Physiology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Astronomical and Space Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
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rattus norvegicus </
rattus norvegicus ,</
hind limb unloaded
div >< p
decreased cytokine production
persistent health effects
cardiac fibrosis present
galactic cosmic radiation
disrupt calcium homeostasis
simplified gcr simulation
study involved exposure
findings show exposure
75 gy simgcrsim
myeloid cells compared
5 gy simgcrsim
5 gy
combined effects
cardiac disease
space radiation
calcium dynamics
5 days
radiation dose
weightlessness alone
taken together
spaceflight stressors
secondary endpoints
primary endpoint
male wag
limited interactions
limited follow
immune system
immune function
identified mutations
human disease
gene variants
extended follow
depleted cd56
appropriate controls
also measured
alone engaged
administered rapidly
360 days
270 days
25 days
<p>Ratios <1 show a relative decrease in cytokines for sham irradiation with HLU vs. sham irradiation no HLU. Ratios >1 show a relative increase in cytokines for HLU vs no HLU. <i>n</i> = 10 rats per group. A mixed effects model with random intercept was fitted to the log-transformed the value of each cytokine as the outcome variable. Fixed effects for sampling time and study group were included. Pairwise comparisons between the groups were performed, with no adjustment for multiple testing. Benjamini & Hochberg method (“fdr”) is used for p value adjustment between cytokines.</p>
2026-09-30T17:24:54Z
Image
Figure
10.1371/journal.pone.0357485.g006
https://figshare.com/articles/figure/_p_Comparative_changes_in_cytokines_present_in_the_circulation_30_270_days_after_sham-irradiation_with_HLU_compared_with_sham-irradiation_no_HLU_p_/34034485
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