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2026-09-30T17:25:17Z
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<p>Depletion of components of the immune system in spleen.</p>
Marek Lenarczyk (11483998)
Amy Kronenberg (4229725)
Andy Kwok (11484016)
Alexander Borg (10656692)
Ammar J. Alsheikh (25145023)
Angela J. Mathison (7335572)
Michael T. Zimmermann (161961)
Samuel B. R. Lawton (25145026)
Hershel Raff (365791)
Jeffrey Willey (10341092)
Richard A. Komorowski (25145029)
Raul Urrutia (1537)
John E. Baker (15360761)
Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Genetics
Physiology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Astronomical and Space Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
sup >+</ sup
rattus norvegicus </
rattus norvegicus ,</
hind limb unloaded
div >< p
decreased cytokine production
persistent health effects
cardiac fibrosis present
galactic cosmic radiation
disrupt calcium homeostasis
simplified gcr simulation
study involved exposure
findings show exposure
75 gy simgcrsim
myeloid cells compared
5 gy simgcrsim
5 gy
combined effects
cardiac disease
space radiation
calcium dynamics
5 days
radiation dose
weightlessness alone
taken together
spaceflight stressors
secondary endpoints
primary endpoint
male wag
limited interactions
limited follow
immune system
immune function
identified mutations
human disease
gene variants
extended follow
depleted cd56
appropriate controls
also measured
alone engaged
administered rapidly
360 days
270 days
25 days
<p>A. Areas positive for biomarkers of natural killer cells (CD56<sup>+</sup>) in spleen 270 days after sham irradiation no HLU, sham irradiation with HLU, whole body exposure to simGCRsim no HLU, and simGCRsim with HLU. The horizontal bar represents 500 microns. B. The CD<sup>+</sup> content of the spleen was defined as the area of CD<sup>+</sup> positive staining cells, expressed as a percentage of the total tissue area. Data are mean ± SD, n = 6 animals per group. Statistical analysis was conducted using a t-test.</p>
2026-09-30T17:24:54Z
Image
Figure
10.1371/journal.pone.0357485.g005
https://figshare.com/articles/figure/_p_Depletion_of_components_of_the_immune_system_in_spleen_p_/34034482
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