2026-10-07T13:28:56Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34034479
2026-09-30T17:25:15Z
category_1
category_4
category_915
category_7
category_12
category_13
category_16
category_19
category_21
category_873
category_502
category_46
category_734
category_64
category_132
portal_5
item_type_1
month_year_09_2026
<p>Measurement of numbers of discrete components of the immune system in peripheral blood.</p>
Marek Lenarczyk (11483998)
Amy Kronenberg (4229725)
Andy Kwok (11484016)
Alexander Borg (10656692)
Ammar J. Alsheikh (25145023)
Angela J. Mathison (7335572)
Michael T. Zimmermann (161961)
Samuel B. R. Lawton (25145026)
Hershel Raff (365791)
Jeffrey Willey (10341092)
Richard A. Komorowski (25145029)
Raul Urrutia (1537)
John E. Baker (15360761)
Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Genetics
Physiology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
Astronomical and Space Sciences not elsewhere classified
Immunology
Biological Sciences not elsewhere classified
Cancer
Infectious Diseases
sup >+</ sup
rattus norvegicus </
rattus norvegicus ,</
hind limb unloaded
div >< p
decreased cytokine production
persistent health effects
cardiac fibrosis present
galactic cosmic radiation
disrupt calcium homeostasis
simplified gcr simulation
study involved exposure
findings show exposure
75 gy simgcrsim
myeloid cells compared
5 gy simgcrsim
5 gy
combined effects
cardiac disease
space radiation
calcium dynamics
5 days
radiation dose
weightlessness alone
taken together
spaceflight stressors
secondary endpoints
primary endpoint
male wag
limited interactions
limited follow
immune system
immune function
identified mutations
human disease
gene variants
extended follow
depleted cd56
appropriate controls
also measured
alone engaged
administered rapidly
360 days
270 days
25 days
<p>Immune cell numbers of total leukocytes (CD45<sup>+</sup>), T lymphocytes (CD3<sup>+</sup>), helper T lymphocytes (CD3<sup>+</sup>/CD4<sup>+</sup>), cytotoxic T lymphocytes (CD3<sup>+</sup>/CD8<sup>+</sup>), myeloid cells (CD11bc<sup>+</sup>) and B lymphocytes (CD45R<sup>+</sup>) in circulation 240 days after whole body exposure to simGCRsim, HLU, and simGCRsim plus HLU. NS = not significant. Data are mean ± SD, <i>n</i> = 6 animals per group. Statistical analysis was conducted using a t-test.</p>
2026-09-30T17:24:54Z
Image
Figure
10.1371/journal.pone.0357485.g004
https://figshare.com/articles/figure/_p_Measurement_of_numbers_of_discrete_components_of_the_immune_system_in_peripheral_blood_p_/34034479
CC BY 4.0