2026-10-09T16:51:04Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34034469 2026-09-30T17:40:03Z category_7 category_19 category_21 category_734 category_106 category_132 portal_5 item_type_1 month_year_09_2026

<p>The conceptual framework illustrates the impact of climate change on pharmaceuticals and patient clinical outcomes.</p> Pono Pono (25145034) Alan M. Jones (52267) Medicine Pharmacology Biotechnology Biological Sciences not elsewhere classified Science Policy Infectious Diseases potentially reducing efficacy emerging evidence shows challenges remains fragmented affect drug stability adverse drug events review synthesises evidence particularly extreme heat climate &# 8209 assessing potential implications altering pharmaceutical formulations pharmaceuticals </ p increasing disease burden diseases affecting cardiovascular disease burden pharmaceutical treatments review found review finds drug safety urgent need threatening access thermoregulatory system therapeutic response support resilient respiratory systems related stressors potential impact patient responses older adults integrated research increased morbidity human health high temperature health systems current knowledge climate change chronic diseases <p>Climate change stressors affect the physiological function of the cardiovascular, cerebrovascular, and renal systems, thereby inducing dehydration and electrolyte imbalances and impairing thermoregulation. These changes alter pharmacokinetics and simultaneously affect drug stability and pharmaceutical formulation. These changes collectively modify drug safety, efficacy, and therapeutic outcomes.</p> 2026-09-30T17:40:01Z Image Figure 10.1371/journal.pclm.0001068.g002 https://figshare.com/articles/figure/_p_The_conceptual_framework_illustrates_the_impact_of_climate_change_on_pharmaceuticals_and_patient_clinical_outcomes_p_/34034469 CC BY 4.0