2026-10-08T02:21:46Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34034449 2026-09-30T17:25:01Z category_1 category_4 category_915 category_7 category_12 category_13 category_16 category_19 category_21 category_873 category_502 category_46 category_734 category_64 category_132 portal_5 item_type_6 month_year_09_2026

<p>Risk factors for cardiac disease and kidney injury after irradiation of rats with simGCRsim no HLU.</p> Marek Lenarczyk (11483998) Amy Kronenberg (4229725) Andy Kwok (11484016) Alexander Borg (10656692) Ammar J. Alsheikh (25145023) Angela J. Mathison (7335572) Michael T. Zimmermann (161961) Samuel B. R. Lawton (25145026) Hershel Raff (365791) Jeffrey Willey (10341092) Richard A. Komorowski (25145029) Raul Urrutia (1537) John E. Baker (15360761) Biophysics Biochemistry Physical Sciences not elsewhere classified Medicine Cell Biology Genetics Physiology Pharmacology Biotechnology Chemical Sciences not elsewhere classified Astronomical and Space Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer Infectious Diseases sup >+</ sup rattus norvegicus </ rattus norvegicus ,</ hind limb unloaded div >< p decreased cytokine production persistent health effects cardiac fibrosis present galactic cosmic radiation disrupt calcium homeostasis simplified gcr simulation study involved exposure findings show exposure 75 gy simgcrsim myeloid cells compared 5 gy simgcrsim 5 gy combined effects cardiac disease space radiation calcium dynamics 5 days radiation dose weightlessness alone taken together spaceflight stressors secondary endpoints primary endpoint male wag limited interactions limited follow immune system immune function identified mutations human disease gene variants extended follow depleted cd56 appropriate controls also measured alone engaged administered rapidly 360 days 270 days 25 days <p>Absolute values for total cholesterol (upper left), triglycerides (upper right), blood urea nitrogen (lower left) and total protein (lower right) following sham irradiation no HLU compared with simGCRsim 1.5 Gy no HLU. Data are means ± SD, <i>n</i> = 11–12/group. * = p < 0.05 vs. age-matched control. Statistical analysis was conducted using a t-test.</p> <p>(PDF)</p> 2026-09-30T17:24:54Z Text Journal contribution 10.1371/journal.pone.0357485.s005 https://figshare.com/articles/journal_contribution/_p_Risk_factors_for_cardiac_disease_and_kidney_injury_after_irradiation_of_rats_with_simGCRsim_no_HLU_p_/34034449 CC BY 4.0