2026-10-14T11:38:22Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34034019 2026-09-30T16:27:38Z category_4 category_7 category_873 category_45 category_734 category_132 portal_63 item_type_6 month_year_09_2026

Transition-Metal-Free Regioselective Construction of Cyano- and Phosphonyl Tetrazole Derivatives Yufeng Wang (274657) Zeya Xu (10921395) Ruiqi Liu (3873832) Yuting Zheng (2176086) Jia Zhou (53252) Xiaoran Chen (11616265) Tingpu Guo (25144899) Yulei Zhao (3129630) Biochemistry Medicine Chemical Sciences not elsewhere classified Sociology Biological Sciences not elsewhere classified Infectious Diseases phosphonyl tetrazole derivatives precious metal catalysts free regioselective construction substituted tetrazoles scale reactions regioselective synthesis promising applications product transformation nearly ineffective natural products enhances safety dual tetrazoles brønsted base arylazo sulfones also avoids A Brønsted base-promoted, transition-metal-free [3 + 2] cycloaddition for the regioselective synthesis of cyano- and phosphonyl-substituted tetrazoles is reported. Compared to readily decomposing diazonium salts, the use of arylazo sulfones not only enhances safety but also avoids the need for precious metal catalysts. Arylazo sulfones exhibit excellent reactivity, whereas other commonly used azo compounds are nearly ineffective. Modification of natural products, synthesis of dual tetrazoles, gram-scale reactions, and investigations into product transformation further highlight the promising applications. 2026-09-30T00:00:00Z Text Journal contribution 10.1021/acs.joc.6c01824.s001 https://figshare.com/articles/journal_contribution/Transition-Metal-Free_Regioselective_Construction_of_Cyano-_and_Phosphonyl_Tetrazole_Derivatives/34034019 CC BY-NC 4.0